PMID- 19121837
OWN - NLM
STAT- MEDLINE
DCOM- 20090424
LR  - 20121115
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 74
IP  - 9
DP  - 2009 Mar
TI  - Oxidative stress and histopathology damage related to the metabolism of 
      dodecylbenzene sulfonate in Senegalese sole.
PG  - 1216-23
LID - 10.1016/j.chemosphere.2008.11.032 [doi]
AB  - Surfactants such as linear alkylbenzene sulfonates (LAS) are widely utilised in 
      the formulation of detergents in commercial products. After use, they pass 
      through waste water treatment plants (WWTP) and are then discharged to aquatic 
      ecosystems, causing risk to aquatic life. The exposure of marine animals to these 
      compounds enhances the production of reactive oxygen species (ROS) with 
      subsequent damage to macromolecules, and produces histological alterations. A 
      flow-through experiment with Senegalese sole (Solea senegalensis) has been 
      devised with the object of correlating the metabolism of LAS including 
      sulfophenylcarboxylic acids (SPCs) by fish with their antioxidant defence system 
      (generation of oxyradicals) and histopathological damage. The generation of 
      intermediate degradation products (SPCs) by the organism, the histopathological 
      responses, the antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPX), 
      glutathione reductase (GR), and glutathione S-transferase (GST)), as well as 
      other kinds of enzyme such as acid and alkaline phosphatases (AcP, ALP), were 
      measured. SPCs from 5OC(6) to 11OC(12) were identified and quantified in fish and 
      water; their concentrations differed depending on the sampling moment. In 
      general, the responses found in the enzymes were slight: a decrease in the 
      enzymatic activity in gills and activation in the digestive tract. The evidence 
      of histopathological damage identified was also small; the organism's defensive 
      mechanism against pollutants should enable it to recover easily. A direct 
      relationship was established between biotransformation and the generation of SPCs 
      and ROS. In conclusion, the correct functioning of the antioxidant defence system 
      with absence of large variations, the short-term histopathological damage, and 
      the evidence of SPCs indicate an adequate metabolism of 2-phenyl-C(12)-linear 
      alkylbenzene sulfonates (2OC(12)LAS) by this specie and non-toxic effects at 
      environmentally realistic levels.
FAU - Alvarez-Munoz, D
AU  - Alvarez-Munoz D
AD  - Dpto. Quimica Fisica, Facultad de Ciencias del Mar y Ambientales, Universidad de 
      Cadiz, Avd Republica Saharaui s/n, 11510 Puerto Real, Cadiz, Spain.
FAU - Gomez-Parra, A
AU  - Gomez-Parra A
FAU - Blasco, J
AU  - Blasco J
FAU - Sarasquete, C
AU  - Sarasquete C
FAU - Gonzalez-Mazo, E
AU  - Gonzalez-Mazo E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090103
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Benzenesulfonates)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Surface-Active Agents)
RN  - 0 (Water Pollutants, Chemical)
RN  - 60NSK897G9 (dodecylbenzenesulfonic acid)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Animals
MH  - Benzenesulfonates/metabolism/*toxicity
MH  - Catalase/metabolism
MH  - Flatfishes/*metabolism
MH  - Gene Expression Regulation, Enzymologic/*drug effects
MH  - Glutathione Peroxidase/metabolism
MH  - Glutathione Reductase/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Reactive Oxygen Species/metabolism
MH  - Surface-Active Agents/metabolism/*toxicity
MH  - Water Pollutants, Chemical/metabolism/*toxicity
EDAT- 2009/01/06 09:00
MHDA- 2009/04/25 09:00
CRDT- 2009/01/06 09:00
PHST- 2008/07/11 00:00 [received]
PHST- 2008/10/27 00:00 [revised]
PHST- 2008/11/10 00:00 [accepted]
PHST- 2009/01/06 09:00 [entrez]
PHST- 2009/01/06 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
AID - S0045-6535(08)01418-5 [pii]
AID - 10.1016/j.chemosphere.2008.11.032 [doi]
PST - ppublish
SO  - Chemosphere. 2009 Mar;74(9):1216-23. doi: 10.1016/j.chemosphere.2008.11.032. Epub 
      2009 Jan 3.