PMID- 19125162
OWN - NLM
STAT- MEDLINE
DCOM- 20091014
LR  - 20090216
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 33
IP  - 2
DP  - 2009 Feb
TI  - Alcohol consumption promotes insulin sensitivity without affecting body fat 
      levels.
PG  - 197-203
LID - 10.1038/ijo.2008.266 [doi]
AB  - OBJECTIVE: Alcohol consumption promotes insulin sensitivity. In obesity, a 
      decrease in body fat levels decreases the risk of developing insulin resistance; 
      therefore, it is possible that alcohol improves insulin sensitivity by negatively 
      affecting body fat. The aim of this study was to determine whether alcohol 
      consumption promotes insulin sensitivity by reducing body fat levels in C57BL/6 
      male mice. METHODS: We examined the effects of alcohol consumption on insulin 
      sensitivity in male mice with three different body weight (BW) phenotypes. The 
      BWs were induced by feeding the mice a 30% calorie-restricted (CR) regimen, a 
      low-fat (LF) diet and a high-fat (HF) diet. The mice had free access to water or 
      20% ethanol in the drinking water. To determine the effects of the three 
      different BW phenotypes and of alcohol on glucose regulation and insulin 
      sensitivity, we performed the insulin tolerance test (ITT) and glucose tolerance 
      test (GTT) on the mice. The effects of the diets and alcohol on body composition, 
      percent body fat (% BF), percent lean mass and bone mineral density (BMD) were 
      determined by dual-energy X-ray absorptiometry (DEXA). RESULTS: Data show that 
      mice with the highest body fat levels (HF) were insulin resistant and glucose 
      intolerant. In contrast, mice with the lowest body fat levels (CR) were the most 
      insulin sensitive and cleared the injected endogenous glucose the fastest. 
      Results show that alcohol did not affect GTT in any of the BW phenotypes. 
      However, alcohol consumption promoted insulin sensitivity in mice consuming both 
      the LF and HF diets. Alcohol consumption increased insulin sensitivity without 
      affecting body fat levels, as body fat levels were similar in mice consuming the 
      LF or HF diets and drinking either water or alcohol. CONCLUSIONS: Alcohol 
      consumption promotes insulin sensitivity without affecting body fat levels in 
      mice consuming LF and HF diets.
FAU - Hong, J
AU  - Hong J
AD  - Department of Human Ecology, Division of Nutritional Sciences, University of 
      Texas at Austin, Austin, TX 78712, USA.
FAU - Smith, R R
AU  - Smith RR
FAU - Harvey, A E
AU  - Harvey AE
FAU - Nunez, N P
AU  - Nunez NP
LA  - eng
GR  - 1K22CA127519-01A1/CA/NCI NIH HHS/United States
GR  - ES007784/ES/NIEHS NIH HHS/United States
GR  - ES09145/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090106
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adipose Tissue/anatomy & histology/*physiology
MH  - *Alcohol Drinking/metabolism
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Body Weight/*physiology
MH  - Diet
MH  - Glucose Tolerance Test
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
EDAT- 2009/01/07 09:00
MHDA- 2009/10/15 06:00
CRDT- 2009/01/07 09:00
PHST- 2009/01/07 09:00 [entrez]
PHST- 2009/01/07 09:00 [pubmed]
PHST- 2009/10/15 06:00 [medline]
AID - ijo2008266 [pii]
AID - 10.1038/ijo.2008.266 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2009 Feb;33(2):197-203. doi: 10.1038/ijo.2008.266. Epub 2009 
      Jan 6.