PMID- 19125420
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20131121
IS  - 0951-4198 (Print)
IS  - 0951-4198 (Linking)
VI  - 23
IP  - 3
DP  - 2009 Feb
TI  - Rapid detection of drugs in biofluids using atmospheric pressure chemi/chemical 
      ionization mass spectrometry.
PG  - 333-9
LID - 10.1002/rcm.3877 [doi]
AB  - We have demonstrated that, with simple pH adjustment, volatile drugs such as 
      methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), ketamine, 
      and valproic acid could be analyzed rapidly from raw biofluid samples (e.g. urine 
      and serum) without dilution, or extraction, using atmospheric pressure 
      ionization. The ion source was a variant type of atmospheric pressure chemical 
      ionization (APCI) that used a dielectric barrier discharge (DBD) to generate the 
      metastable helium gas and reagent ions. The sample solution was loaded in a 
      disposable glass pipette, and the volatile compounds were purged by nitrogen gas 
      to be reacted with the metastable helium gas. The electrodes of the DBD were 
      arranged in such a way that the generated glow discharge was confined within the 
      discharge tube and was not exposed to the analytes. A needle held at 100-500 V 
      was placed between the ion-sampling orifice and the discharge tube to guide the 
      analyte ions into the mass spectrometer. After pH adjustment of the biofluid 
      sample, the amphiphilic drugs were in the form of a water-insoluble oil, which 
      could be concentrated on the liquid surface. By gentle heating of the sample to 
      increase the evaporation rate, rapid and sensitive detection of these drugs in 
      raw urine and serum samples could be achieved in less than 2 min for each sample.
CI  - Copyright 2009 John Wiley & Sons, Ltd.
FAU - Chen, Lee Chuin
AU  - Chen LC
AD  - Clean Energy Research Center, University of Yamanashi, 4-3-11 Takeda, Kofu, 
      Yamanashi 400-8511, Japan.
FAU - Hashimoto, Yutaka
AU  - Hashimoto Y
FAU - Furuya, Hiroko
AU  - Furuya H
FAU - Takekawa, Kenichi
AU  - Takekawa K
FAU - Kubota, Takeo
AU  - Kubota T
FAU - Hiraoka, Kenzo
AU  - Hiraoka K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Amphetamines)
RN  - 0 (Ions)
RN  - 0 (Volatile Organic Compounds)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Amphetamines/blood/urine
MH  - Atmospheric Pressure
MH  - Humans
MH  - Ions/chemistry
MH  - Ketamine/blood/urine
MH  - *Mass Spectrometry/instrumentation/methods
MH  - Models, Chemical
MH  - Reference Standards
MH  - Sensitivity and Specificity
MH  - Substance Abuse Detection/methods
MH  - Valproic Acid/blood/urine
MH  - Volatile Organic Compounds/*blood/*urine
EDAT- 2009/01/07 09:00
MHDA- 2009/03/07 09:00
CRDT- 2009/01/07 09:00
PHST- 2009/01/07 09:00 [entrez]
PHST- 2009/01/07 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
AID - 10.1002/rcm.3877 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2009 Feb;23(3):333-9. doi: 10.1002/rcm.3877.