PMID- 19126013
OWN - NLM
STAT- MEDLINE
DCOM- 20090429
LR  - 20090107
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 47
IP  - 12
DP  - 2008 Dec
TI  - Diffuse cutaneous leishmaniasis associated with the immune reconstitution 
      inflammatory syndrome.
PG  - 1263-70
LID - 10.1111/j.1365-4632.2008.03804.x [doi]
AB  - Leishmaniasis is an emerging disease in HIV-infected persons; visceral 
      leishmaniasis is an AIDS-defining opportunistic infection. The parasite that 
      causes this infection is usually transmitted by the sandfly and occasionally by 
      nonsterile needles among intravenous drug users. Diffuse cutaneous leishmaniasis 
      (DCL) is a rare anergic variant of leishmanial infection with the characteristic 
      presentation of numerous nonulcerating nodules with an abundant parasite load, 
      lack of visceral involvement, negative reaction to the leishmanin skin test, and 
      a chronic course with incomplete response to treatment and frequent relapses. We 
      report a case of DCL that developed in the context of the immune reconstitution 
      inflammatory syndrome (IRIS) in a man with AIDS following initiation of 
      antiretroviral therapy. We also review DCL to emphasize the importance of 
      recognizing and treating this evolving disease in the growing population of 
      patients on immunorestorative therapy.
FAU - Sinha, Smeeta
AU  - Sinha S
AD  - Dermatology, Infectious Diseases and Pathology, New Jersey Medical School, 
      Newark, New Jersey, USA.
FAU - Fernandez, Geover
AU  - Fernandez G
FAU - Kapila, Rajendra
AU  - Kapila R
FAU - Lambert, W Clark
AU  - Lambert WC
FAU - Schwartz, Robert A
AU  - Schwartz RA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications
MH  - Acquired Immunodeficiency Syndrome/drug therapy
MH  - Adult
MH  - Animals
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*complications
MH  - Leishmania donovani
MH  - Leishmaniasis, Diffuse Cutaneous/*complications/pathology
MH  - Male
EDAT- 2009/01/08 09:00
MHDA- 2009/04/30 09:00
CRDT- 2009/01/08 09:00
PHST- 2009/01/08 09:00 [entrez]
PHST- 2009/01/08 09:00 [pubmed]
PHST- 2009/04/30 09:00 [medline]
AID - IJD3804 [pii]
AID - 10.1111/j.1365-4632.2008.03804.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2008 Dec;47(12):1263-70. doi: 10.1111/j.1365-4632.2008.03804.x.