PMID- 19126661
OWN - NLM
STAT- MEDLINE
DCOM- 20090527
LR  - 20221207
IS  - 1470-3203 (Print)
IS  - 1470-3203 (Linking)
VI  - 9
IP  - 4
DP  - 2008 Dec
TI  - Association of insertion/deletion polymorphism of angiotensin-converting enzyme 
      gene with essential hypertension and type 2 diabetes mellitus in Malaysian 
      subjects.
PG  - 208-14
LID - 10.1177/1470320308097499 [doi]
AB  - INTRODUCTION: The deletion (D) allele of the angiotensin-converting enzyme (ACE) 
      gene has been studied in various populations in relation to hypertension (HTN) 
      and type 2 diabetes mellitus (T2DM) with contradictory results. This study sought 
      to determine the association of insertion (I)/D polymorphism of the ACE gene in 
      hypertensive and T2DM subjects in a Malaysian population. MATERIALS AND METHODS: 
      A total of 260 subjects consisting of 65 HTN, 60 T2DM, 65 T2DM with HTN and 70 
      controls were recruited. Genotyping was performed by polymerase chain reaction 
      initially and mistyping of DD genotypes was performed with an insertion-specific 
      primer. RESULTS: The frequency for II, ID and DD genotypes of the ACE gene was 
      36.92%, 52.31% and 10.77% in HTN, 40.00%, 41.67% and 18.33% inT2DM, 30.77%, 
      53.85% and 15.38% inT2DM with HTN and 57.14%, 40.00% and 2.86% in controls, 
      respectively. The frequency for the D allele was 36.92% in HTN, 39.17% in T2DM 
      and 42.31% in T2DM with HTN compared to 22.86% in controls. The genotype and 
      allele frequency of the ACE gene polymorphism differed significantly in patients 
      when compared to controls (p < 0.05). CONCLUSION: The D allele of the ACE gene is 
      associated with essential HTN and T2DM in Malaysian subjects.
FAU - Ramachandran, Vasudevan
AU  - Ramachandran V
AD  - Molecular Biology Laboratory, Department of Biomedical Sciences, Faculty of 
      Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, 
      Malaysia.
FAU - Ismail, Patimah
AU  - Ismail P
FAU - Stanslas, Johnson
AU  - Stanslas J
FAU - Shamsudin, Norashikin
AU  - Shamsudin N
FAU - Moin, Saidi
AU  - Moin S
FAU - Mohd Jas, Rusni
AU  - Mohd Jas R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/*enzymology/genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Hypertension/*complications/*enzymology/genetics
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - *Polymorphism, Genetic
MH  - Sex Characteristics
EDAT- 2009/01/08 09:00
MHDA- 2009/05/28 09:00
CRDT- 2009/01/08 09:00
PHST- 2009/01/08 09:00 [entrez]
PHST- 2009/01/08 09:00 [pubmed]
PHST- 2009/05/28 09:00 [medline]
AID - 9/4/208 [pii]
AID - 10.1177/1470320308097499 [doi]
PST - ppublish
SO  - J Renin Angiotensin Aldosterone Syst. 2008 Dec;9(4):208-14. doi: 
      10.1177/1470320308097499.