PMID- 19128831
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20161125
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 33
IP  - 10
DP  - 2009 Oct
TI  - Y-chromosome loss as the sole karyotypic anomaly with 3'RARalpha submicroscopic 
      deletion in a case of M3r subtype of acute promyelocytic leukemia.
PG  - 1433-5
LID - 10.1016/j.leukres.2008.11.026 [doi]
AB  - Acute promyelocytic leukemia (APL) is characterized by the presence of a 
      chromosomal rearrangement involving retinoic acid receptor alpha (RARalpha) gene 
      generating the X-RARalpha fusion. We describe here a unique RARalpha gene 
      rearrangement in a patient with M3r subtype of APL. Conventional cytogenetic 
      analysis revealed Y-chromosome loss as the sole karyotypic anomaly. No X-RARalpha 
      fusion was detected by fluorescence in situ hybridization (FISH) using 
      PML/RARalpha dual-color dual-fusion translocation probe set, or RARalpha 
      dual-color break apart rearrangement probe or reverse-transcription polymerase 
      chain reaction (RT-PCR). However, FISH using RARalpha dual-color break apart 
      rearrangement probe showed a deletion of the entire 3'-end of one allele of 
      RARalpha gene. To our knowledge, this is the first documented APL with 3'RARalpha 
      submicroscopic deletion which is not associated with X-RARalpha fusion. The 
      molecular consequences of this anomaly remain to be elucidated.
FAU - Han, Yongsheng
AU  - Han Y
AD  - The First Affiliated Hospital of Soochow University, Jiangsu Institute of 
      Hematology, Key Laboratory of Thrombosis and Hemostasis, 188 Shizi Street, 
      Suzhou, 215006, PR China.
FAU - Xue, Yongquan
AU  - Xue Y
FAU - Zhang, Jun
AU  - Zhang J
FAU - Pan, Jinlan
AU  - Pan J
FAU - Wu, Yafang
AU  - Wu Y
FAU - Bai, Shuxiao
AU  - Bai S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090106
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Y/*genetics
MH  - Disseminated Intravascular Coagulation/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics/pathology
MH  - Partial Thromboplastin Time
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoic Acid Receptor alpha
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Young Adult
EDAT- 2009/01/09 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/01/09 09:00
PHST- 2008/09/11 00:00 [received]
PHST- 2008/11/20 00:00 [revised]
PHST- 2008/11/25 00:00 [accepted]
PHST- 2009/01/09 09:00 [entrez]
PHST- 2009/01/09 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S0145-2126(08)00527-4 [pii]
AID - 10.1016/j.leukres.2008.11.026 [doi]
PST - ppublish
SO  - Leuk Res. 2009 Oct;33(10):1433-5. doi: 10.1016/j.leukres.2008.11.026. Epub 2009 
      Jan 6.