PMID- 19128930
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20151119
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 24
IP  - 4
DP  - 2010 May
TI  - The role of oxidative stress and antioxidant defenses in Buerger disease and 
      atherosclerotic peripheral arterial occlusive disease.
PG  - 455-60
LID - 10.1016/j.avsg.2008.11.006 [doi]
AB  - The aim of this study was to determine the status and the role of oxidative 
      stress and antioxidant defenses in patients with Buerger disease and 
      atherosclerotic peripheral arterial occlusive disease (PAOD). Seventy-three 
      subjects resembling each other in general characteristics were involved in the 
      study: 21 with lower extremity PAOD (mean age 53.05 +/- 10.8 years, 17 men and 
      four women), 22 with Buerger disease (mean age 38.59 +/- 6.4 years, 19 men and 
      three women), and 30 healthy volunteers (mean age 38.59 +/- 6.4 years, 22 men and 
      eight women). We measured the levels of plasma malondialdehyde (MDA), paraoxonase 
      (PON1), protein carbonyls, arylesterase, nitric oxide (NO), serum oxidized 
      low-density lipoprotein (ox-LDL) and MDA, glutathione (GSH), glutathione 
      reductase (GSH-red), glutathione peroxidase (GSH-px), superoxide dismutase (SOD), 
      and catalase (CAT) in erythrocytes. Plasma protein carbonyls, serum ox-LDL, and 
      plasma and erythrocyte MDA were significantly high in the Buerger disease group 
      compared to the PAOD and control groups (p < 0.001). Plasma PON1 levels and GSH 
      and GSH-px levels in erythrocytes in the Buerger disease group were significantly 
      low compared to the PAOD and control groups (p < 0.001). GSH-red, SOD, and CAT 
      levels in erythrocytes in the Buerger disease group were significantly 
      lowcompared to the PAOD group (p < 0.01, p < 0.001, and p < 0.001, respectively). 
      NO levels were significantly lower in the PAOD group compared to the control 
      group (p < 0.05). The balance between oxidative stress and antioxidant capacity 
      is more seriously impaired in Buerger disease than PAOD.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - Arslan, Caner
AU  - Arslan C
AD  - Cardiovascular Surgery Department, TDV 29 Mayis Hospital, Istanbul, Turkey. 
      canerkvc@yahoo.com
FAU - Altan, Hakan
AU  - Altan H
FAU - Besirli, Kazim
AU  - Besirli K
FAU - Aydemir, Birsen
AU  - Aydemir B
FAU - Kiziler, Ali Riza
AU  - Kiziler AR
FAU - Denli, Seyma
AU  - Denli S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090106
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/*metabolism
MH  - Atherosclerosis/*blood
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Lipid Peroxidation
MH  - Male
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Peripheral Vascular Diseases/*blood
MH  - Protein Carbonylation
MH  - Thromboangiitis Obliterans/*blood
EDAT- 2009/01/09 09:00
MHDA- 2010/08/13 06:00
CRDT- 2009/01/09 09:00
PHST- 2008/08/23 00:00 [received]
PHST- 2008/11/12 00:00 [revised]
PHST- 2008/11/16 00:00 [accepted]
PHST- 2009/01/09 09:00 [entrez]
PHST- 2009/01/09 09:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - S0890-5096(08)00421-4 [pii]
AID - 10.1016/j.avsg.2008.11.006 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2010 May;24(4):455-60. doi: 10.1016/j.avsg.2008.11.006. Epub 2009 
      Jan 6.