PMID- 19129392
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 1
DP  - 2009 Jan 7
TI  - Intracerebral dendritic cells critically modulate encephalitogenic versus 
      regulatory immune responses in the CNS.
PG  - 140-52
LID - 10.1523/JNEUROSCI.2199-08.2009 [doi]
AB  - Dendritic cells (DCs) appear in higher numbers within the CNS as a consequence of 
      inflammation associated with autoimmune disorders, such as multiple sclerosis, 
      but the contribution of these cells to the outcome of disease is not yet clear. 
      Here, we show that stimulatory or tolerogenic functional states of intracerebral 
      DCs regulate the systemic activation of neuroantigen-specific T cells, the 
      recruitment of these cells into the CNS and the onset and progression of 
      experimental autoimmune encephalomyelitis (EAE). Intracerebral microinjection of 
      stimulatory DCs exacerbated the onset and clinical course of EAE, accompanied 
      with an early T-cell infiltration and a decreased proportion of regulatory 
      FoxP3-expressing cells in the brain. In contrast, the intracerebral 
      microinjection of DCs modified by tumor necrosis factor alpha induced their 
      tolerogenic functional state and delayed or prevented EAE onset. This triggered 
      the generation of interleukin 10 (IL-10)-producing neuroantigen-specific 
      lymphocytes in the periphery and restricted IL-17 production in the CNS. Our 
      findings suggest that DCs are a rate-limiting factor for neuroinflammation.
FAU - Zozulya, Alla L
AU  - Zozulya AL
AD  - Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany.
FAU - Ortler, Sonja
AU  - Ortler S
FAU - Lee, JangEun
AU  - Lee J
FAU - Weidenfeller, Christian
AU  - Weidenfeller C
FAU - Sandor, Matyas
AU  - Sandor M
FAU - Wiendl, Heinz
AU  - Wiendl H
FAU - Fabry, Zsuzsanna
AU  - Fabry Z
LA  - eng
GR  - R56 NS037570/NS/NINDS NIH HHS/United States
GR  - R01-NS 37570-01A2/NS/NINDS NIH HHS/United States
GR  - R01 NS037570-07/NS/NINDS NIH HHS/United States
GR  - R01 NS037570-09A2/NS/NINDS NIH HHS/United States
GR  - R01 NS037570-08/NS/NINDS NIH HHS/United States
GR  - R01 NS037570-10/NS/NINDS NIH HHS/United States
GR  - R56 NS037570-09A1/NS/NINDS NIH HHS/United States
GR  - R01 NS037570-11/NS/NINDS NIH HHS/United States
GR  - R01 NS037570/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Glycoproteins)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukin-7)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Peptide Fragments)
RN  - 0 (myelin oligodendrocyte glycoprotein (35-55))
RN  - 124-87-8 (Picrotoxin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9007-81-2 (Freund's Adjuvant)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Central Nervous System/cytology/*immunology
MH  - Central Nervous System Stimulants
MH  - Dendritic Cells/classification/drug effects/*immunology
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/chemically 
      induced/*immunology/*pathology/prevention & control
MH  - Female
MH  - Flow Cytometry
MH  - Forkhead Transcription Factors/metabolism
MH  - Freund's Adjuvant/adverse effects
MH  - Glycoproteins/adverse effects
MH  - Immune System Phenomena/drug effects/*immunology
MH  - Interferon-alpha/administration & dosage
MH  - Interferon-gamma/metabolism
MH  - Interleukin-7/metabolism
MH  - Lipopolysaccharides/administration & dosage
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mycobacterium tuberculosis
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Peptide Fragments/adverse effects
MH  - Picrotoxin/administration & dosage
MH  - T-Lymphocytes/classification/immunology
MH  - Time Factors
PMC - PMC2942091
MID - NIHMS85911
EDAT- 2009/01/09 09:00
MHDA- 2009/04/09 09:00
PMCR- 2009/07/07
CRDT- 2009/01/09 09:00
PHST- 2009/01/09 09:00 [entrez]
PHST- 2009/01/09 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2009/07/07 00:00 [pmc-release]
AID - 29/1/140 [pii]
AID - 3436344 [pii]
AID - 10.1523/JNEUROSCI.2199-08.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Jan 7;29(1):140-52. doi: 10.1523/JNEUROSCI.2199-08.2009.