PMID- 19131450
OWN - NLM
STAT- MEDLINE
DCOM- 20090618
LR  - 20220331
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 64
IP  - 5
DP  - 2009 May
TI  - Heterogeneity of asthma according to blood inflammatory patterns.
PG  - 374-80
LID - 10.1136/thx.2008.103069 [doi]
AB  - RATIONALE: There is increasing interest regarding asthma heterogeneity in 
      relation to inflammatory patterns. OBJECTIVES: To assess phenotypic 
      characteristics, in particular clinical presentation of the disease, in 381 
      well-characterised adults with asthma from the French Epidemiological study on 
      the Genetics and Environment of Asthma (EGEA) according to their blood 
      inflammatory pattern. METHODS: Four blood inflammatory patterns were defined 
      according to eosinophil (EOS) and neutrophil (NEU) count cut-off points. Samples 
      with > or =250 EOS/mm(3) were classified as EOS(hi) and those with > or =5000 
      NEU/mm(3) as NEU(hi). Clinical characteristics include typical asthma and chronic 
      obstructive pulmonary disease (COPD)-like symptoms, as well as composite 
      quantitative scores addressing the activity of the disease. RESULTS: A 
      substantial number of those with asthma (56.2%) had the EOS(lo) pattern (<250 
      EOS/mm(3)). Patients with asthma who had the EOS(hi) pattern had higher 
      immunoglobulin E (IgE), a lower forced expiratory volume in 1 s (FEV(1)) and 
      presented a more active asthma than those with the EOS(lo) pattern. Among those 
      with the EOS(lo) pattern, neutrophil inflammation (NEU(hi)) was related to a less 
      frequent positive skin prick test response (OR 0.44, 95% CI 0.20 to 0.96). Among 
      those with the EOS(hi) pattern, neutrophil inflammation did not explain current 
      asthma or asthma activity, and was significantly related to nocturnal symptoms 
      (OR 5.21, 95% CI 1.44 to 18.8) independently of age, sex, smoking and inhaled 
      corticosteroid treatment. In non-smokers with asthma, COPD-like symptoms, in 
      particular chronic phlegm, were more frequent in those with neutrophil 
      inflammation, independent of eosinophil inflammation (OR 2.35, 95% CI 1.08 to 
      5.10). CONCLUSIONS: Besides eosinophilia, neutrophil inflammation assessed in the 
      blood is related to specific characteristics of asthma. Considering 
      simultaneously neutrophilic and eosinophilic inflammation may contribute to help 
      to disentangle this complex disease.
FAU - Nadif, R
AU  - Nadif R
AD  - Institut National de la Sante et de la Recherche Medicale, Villejuif, France. 
      rachel.nadif@inserm.fr
FAU - Siroux, V
AU  - Siroux V
FAU - Oryszczyn, M-P
AU  - Oryszczyn MP
FAU - Ravault, C
AU  - Ravault C
FAU - Pison, C
AU  - Pison C
FAU - Pin, I
AU  - Pin I
FAU - Kauffmann, F
AU  - Kauffmann F
CN  - Epidemiological study on the Genetics and Environment of Asthma (EGEA)
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20090108
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
CIN - Thorax. 2009 May;64(5):369-70. PMID: 19401481
MH  - Adult
MH  - Age Factors
MH  - Asthma/*etiology/pathology
MH  - Bronchitis/*pathology
MH  - Chronic Disease
MH  - Cough/etiology/pathology
MH  - Eosinophils/*pathology
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Neutrophils/*pathology
MH  - Phenotype
MH  - Pulmonary Disease, Chronic Obstructive/etiology/pathology
MH  - Pulmonary Eosinophilia/pathology
MH  - Sex Factors
MH  - Young Adult
FIR - Kauffmann, F
IR  - Kauffmann F
FIR - Demenais, F
IR  - Demenais F
FIR - Pin, I
IR  - Pin I
FIR - Korobaeff, M
IR  - Korobaeff M
FIR - Neukirch, F
IR  - Neukirch F
FIR - Annesi-Maesano, I
IR  - Annesi-Maesano I
FIR - Kauffmann, F
IR  - Kauffmann F
FIR - Le Moual, N
IR  - Le Moual N
FIR - Nadif, R
IR  - Nadif R
FIR - Oryszczyn, M P
IR  - Oryszczyn MP
FIR - Siroux, V
IR  - Siroux V
FIR - Feingold, J
IR  - Feingold J
FIR - Dizier, M H
IR  - Dizier MH
FIR - Bouzigon, E
IR  - Bouzigon E
FIR - Demenais, F
IR  - Demenais F
FIR - Gut, I
IR  - Gut I
FIR - Lathrop, M
IR  - Lathrop M
FIR - Pin, I
IR  - Pin I
FIR - Pison, C
IR  - Pison C
FIR - Ecochard, D
IR  - Ecochard D
FIR - Gormand, F
IR  - Gormand F
FIR - Pacheco, Y
IR  - Pacheco Y
FIR - Charpin, D
IR  - Charpin D
FIR - Vervloet, D
IR  - Vervloet D
FIR - Bousquet, J
IR  - Bousquet J
FIR - Lockhart, A
IR  - Lockhart A
FIR - Matran, R
IR  - Matran R
FIR - Paty, E
IR  - Paty E
FIR - Scheinmann, P
IR  - Scheinmann P
FIR - Grimfeld, A
IR  - Grimfeld A
FIR - Just, J
IR  - Just J
FIR - Hochez, J
IR  - Hochez J
FIR - Le Moual, N
IR  - Le Moual N
FIR - Ravault, C
IR  - Ravault C
FIR - Chateigner, N
IR  - Chateigner N
FIR - Ferran, J
IR  - Ferran J
EDAT- 2009/01/10 09:00
MHDA- 2009/06/19 09:00
CRDT- 2009/01/10 09:00
PHST- 2009/01/10 09:00 [entrez]
PHST- 2009/01/10 09:00 [pubmed]
PHST- 2009/06/19 09:00 [medline]
AID - thx.2008.103069 [pii]
AID - 10.1136/thx.2008.103069 [doi]
PST - ppublish
SO  - Thorax. 2009 May;64(5):374-80. doi: 10.1136/thx.2008.103069. Epub 2009 Jan 8.