PMID- 19133129
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220310
IS  - 1757-1626 (Electronic)
IS  - 1757-1626 (Linking)
VI  - 2
IP  - 1
DP  - 2009 Jan 8
TI  - Male infertility related to an aberrant karyotype, 47,XYY: four case reports.
PG  - 28
LID - 10.1186/1757-1626-2-28 [doi]
AB  - BACKGROUND: 47,XYY syndrome is a sex chromosomal abnormality observed in humans, 
      with a prevalence of 0.1% of male births. Sex chromosome anomalies are more 
      frequently associated with male infertility. CASE REPORT: We present here four 
      cases of infertile men with azoospermia or severe oligozoospermia attending a 
      genetic and fertility clinic. Chromosomal analysis of the peripheral blood 
      lymphocytes demonstrated the constitutional karyotype of 47, XYY. Using 
      fluorescence in situ hybridization (FISH) the presence of extra Y chromosome was 
      confirmed, supporting the cytogenetic finding. CONCLUSION: The 47,XYY syndrome is 
      relatively uncommon and can be missed clinically because of its variable clinical 
      presentations. Accurate diagnosis of this constitutional karyotype provides a 
      valuable aid in the counselling and early management of the patients who 
      undertake fertility evaluation.
FAU - El-Dahtory, Faeza
AU  - El-Dahtory F
AD  - The School of Veterinary Medicine and Science, The University of Nottingham, 
      Sutton Bonington Campus, Loughborough, Leicestershire, LE12 5RD, UK. 
      hany.elsheikha@nottingham.ac.uk.
FAU - Elsheikha, Hany M
AU  - Elsheikha HM
LA  - eng
PT  - Journal Article
DEP - 20090108
PL  - England
TA  - Cases J
JT  - Cases journal
JID - 101474272
PMC - PMC2631534
EDAT- 2009/01/10 09:00
MHDA- 2009/01/10 09:01
PMCR- 2009/01/08
CRDT- 2009/01/10 09:00
PHST- 2009/01/03 00:00 [received]
PHST- 2009/01/08 00:00 [accepted]
PHST- 2009/01/10 09:00 [entrez]
PHST- 2009/01/10 09:00 [pubmed]
PHST- 2009/01/10 09:01 [medline]
PHST- 2009/01/08 00:00 [pmc-release]
AID - 1757-1626-2-28 [pii]
AID - 10.1186/1757-1626-2-28 [doi]
PST - epublish
SO  - Cases J. 2009 Jan 8;2(1):28. doi: 10.1186/1757-1626-2-28.