PMID- 19133247
OWN - NLM
STAT- MEDLINE
DCOM- 20090316
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1256
DP  - 2009 Feb 23
TI  - Long-term ginsenoside consumption prevents memory loss in aged SAMP8 mice by 
      decreasing oxidative stress and up-regulating the plasticity-related proteins in 
      hippocampus.
PG  - 111-22
LID - 10.1016/j.brainres.2008.12.031 [doi]
AB  - Ginsenoside, the effective component of ginseng, has been reported to have a 
      neuron protective effect, but the preventive effect on Alzheimer's disease (AD) 
      related memory loss and the underlying mechanisms have not been well determined. 
      The senescence-accelerated mouse (SAM) is a useful model of AD-related memory 
      impairment. In the present study, SAMP8 mice aged 4 months were chronically 
      treated with ginsenoside (3 dose groups were given ginsenoside in drinking water 
      for 7 months). The three groups were treated with ginsenoside 50, 100 and 200 
      mg/kg per day, respectively. Placebo-treated aged mice and young ones (4 months 
      old) were used as controls. In addition, SAMR1 mice were used as "normal aging" 
      control. The beneficial role of ginsenoside was manifested in the prevention of 
      memory loss in aged SAMP8 mice. The optimal dose of ginsenoside is 100 or 200 
      mg/kg per day. In ginsenoside treated groups, the Abeta level markedly decreased 
      in hippocampus and antioxidase level significantly increased in serum. In 
      addition, the plasticity-related proteins in hippocampus significantly increased 
      in the two ginsenoside treated groups. The plasticity-related proteins were 
      checked in the present study including postsynaptic density-95 (PSD-95), 
      phosphor-N-methyl-D-aspartate receptor 1 (p-NMDAR1), phospho-calcium-calmodulin 
      dependent kinase II (p-CaMKII), phospho-protein kinase A Catalyticbeta subunit 
      (p-PKA Cbeta) and protein kinase Cgamma subunit (PKCgamma), phospho-CREB (p-CREB) 
      and brain derived neurotrophic factor (BDNF) etc. These findings suggest that the 
      increase of antioxidation and up-regulation of plasticity-related proteins in 
      hippocampus may be one of the mechanisms of ginsenoside on the memory loss 
      prevention in aged SAMP8 mice.
FAU - Zhao, Haifeng
AU  - Zhao H
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing 100083, PR China.
FAU - Li, Qiong
AU  - Li Q
FAU - Zhang, Zhaofeng
AU  - Zhang Z
FAU - Pei, Xinrong
AU  - Pei X
FAU - Wang, Junbo
AU  - Wang J
FAU - Li, Yong
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081224
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Ginsenosides)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - *Aging
MH  - Amyloid beta-Peptides/metabolism
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Cell Death/drug effects
MH  - Exploratory Behavior/drug effects
MH  - Gene Expression/drug effects
MH  - Ginsenosides/*administration & dosage
MH  - Hippocampus/cytology/*drug effects/metabolism
MH  - Male
MH  - Malondialdehyde/blood
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*prevention & control
MH  - Mice
MH  - Mice, Transgenic
MH  - Motor Activity/drug effects
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/drug effects/ultrastructure
MH  - Oxidative Stress/*drug effects
MH  - Peptide Fragments/metabolism
EDAT- 2009/01/10 09:00
MHDA- 2009/03/17 09:00
CRDT- 2009/01/10 09:00
PHST- 2008/08/23 00:00 [received]
PHST- 2008/12/02 00:00 [revised]
PHST- 2008/12/09 00:00 [accepted]
PHST- 2009/01/10 09:00 [entrez]
PHST- 2009/01/10 09:00 [pubmed]
PHST- 2009/03/17 09:00 [medline]
AID - S0006-8993(08)03007-2 [pii]
AID - 10.1016/j.brainres.2008.12.031 [doi]
PST - ppublish
SO  - Brain Res. 2009 Feb 23;1256:111-22. doi: 10.1016/j.brainres.2008.12.031. Epub 
      2008 Dec 24.