PMID- 19135113
OWN - NLM
STAT- MEDLINE
DCOM- 20090702
LR  - 20111117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 2
DP  - 2009 Feb
TI  - Heterogeneous expression of HLA-G1, -G2, -G5, -G6, and -G7 in myeloid and 
      plasmacytoid dendritic cells isolated from umbilical cord blood.
PG  - 104-9
LID - 10.1016/j.humimm.2008.12.001 [doi]
AB  - Human leukocyte antigen (HLA)-G is a human nonclassic major histocompatibility 
      complex (MHC) molecule characterized by a limited polymorphism and a low, 
      restricted cell surface expression. HLA-G is constitutively expressed on 
      trophoblasts, fetal endothelial, and epithelial cells, conferring alloimmune 
      protection during pregnancy. HLA-G is also expressed in some malignancies and on 
      macrophages and dendritic cells (DC) in tumoral and inflammatory diseases. 
      Because DC constitute an important component in the immune response and umbilical 
      cord blood has a different immune behavior than peripheral blood, the HLA-G 
      protein profile and mRNA expression were investigated on the different DC subsets 
      present in cord blood. Surface and intracellular expression have been reported on 
      DC and HLA-G1, -G2, -G5, -G6, and -G7 transcripts were present. Different levels 
      of soluble HLA-G were obtained from serum and correlated with gene expression. 
      These data are in contrast with the data previously described for adult 
      peripheral blood, where a limited pattern of HLA-G transcripts was reported; only 
      in the maturation process were more isoforms present. These results demonstrate 
      that DC from cord blood have a different behavior than DC in peripheral blood and 
      could be in accordance with the results obtained in cord blood transplantation, 
      where a lesser effect of graft-versus-host disease exists than in bone marrow 
      transplantation.
FAU - Roman, Angela
AU  - Roman A
AD  - Unidad de Inmunoterapia Celular, Centro Nacional de Microbiologia, Instituto de 
      Salud Carlos III, Madrid, Spain.
FAU - Rodriguez, Miriam
AU  - Rodriguez M
FAU - Herraiz, Miguel A
AU  - Herraiz MA
FAU - Jorda, Julia
AU  - Jorda J
FAU - Cervera, Isabel
AU  - Cervera I
FAU - Penaloza, Jorge
AU  - Penaloza J
FAU - Vidart, Jose A
AU  - Vidart JA
FAU - Martinez-Laso, Jorge
AU  - Martinez-Laso J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090107
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Fetal Blood/cytology/*immunology
MH  - Gene Expression Regulation
MH  - Graft vs Host Disease/genetics/immunology/metabolism
MH  - HLA Antigens/blood/*genetics/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/blood/*genetics/*immunology
MH  - Humans
MH  - Leukocytes, Mononuclear/immunology/metabolism
MH  - Myeloid Cells/*immunology
MH  - Pregnancy
MH  - Protein Isoforms/genetics/immunology
MH  - Transplantation, Homologous
EDAT- 2009/01/13 09:00
MHDA- 2009/07/03 09:00
CRDT- 2009/01/13 09:00
PHST- 2008/03/10 00:00 [received]
PHST- 2008/11/17 00:00 [revised]
PHST- 2008/12/04 00:00 [accepted]
PHST- 2009/01/13 09:00 [entrez]
PHST- 2009/01/13 09:00 [pubmed]
PHST- 2009/07/03 09:00 [medline]
AID - S0198-8859(08)00542-9 [pii]
AID - 10.1016/j.humimm.2008.12.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Feb;70(2):104-9. doi: 10.1016/j.humimm.2008.12.001. Epub 2009 
      Jan 7.