PMID- 19136278
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20090302
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 45
IP  - 3
DP  - 2009 Mar
TI  - Transforming growth factor beta 1 (TGFbeta1) gene polymorphisms and Chagas 
      disease susceptibility in Peruvian and Colombian patients.
PG  - 149-53
LID - 10.1016/j.cyto.2008.11.013 [doi]
AB  - Susceptibility to Chagas disease infections and its clinical manifestations may 
      be influenced by host genetic factors. Among cytokines, the multifunctional 
      transforming growth factor beta 1 (TGFbeta1), plays a major role in the 
      establishment and pathogenesis of Trypanosoma cruzi infection, the etiological 
      agent of Chagas disease. Several single-nucleotide polymorphisms (SNP) in the 
      TGFbeta1 gene that may affect cytokine production have been described. We 
      investigated, by PCR methods, five SNP in the TGFbeta1 gene of known or suggested 
      functional significance (-988 C/A; -800 G/A; -509 C/T; 10 T/C and 263 C/T) in 347 
      seropositive (asymptomatic, n=175; cardiomyopathic, n=172) and 279 seronegative 
      unrelated individuals from a Peruvian and a Colombian population where T. cruzi 
      is highly endemic. We found a significant difference in the distribution of the 
      TGFbeta1 10T and 10C alleles between patients and healthy controls in both 
      cohorts, analyzed independently and combined. The frequency of the high TGFbeta1 
      producer genotype 10 C/C was increased in the patients groups of both 
      populations. Our data suggests that TGFbeta1 genetic polymorphisms at codon 10 
      may be involved in a differential susceptibility to T. cruzi infection in these 
      South American samples.
FAU - Calzada, Jose E
AU  - Calzada JE
AD  - Instituto Conmemorativo Gorgas de Estudios de la Salud, P.O. Box 0816-02593, 
      Panama. jcalzada@gorgas.gob.pa
FAU - Beraun, Yasmina
AU  - Beraun Y
FAU - Gonzalez, Clara I
AU  - Gonzalez CI
FAU - Martin, Javier
AU  - Martin J
LA  - eng
PT  - Journal Article
DEP - 20090110
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chagas Disease/epidemiology/*genetics
MH  - Cohort Studies
MH  - Colombia/epidemiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peru/epidemiology
MH  - Polymorphism, Single Nucleotide
MH  - Transforming Growth Factor beta1/*genetics
EDAT- 2009/01/13 09:00
MHDA- 2009/05/15 09:00
CRDT- 2009/01/13 09:00
PHST- 2008/03/10 00:00 [received]
PHST- 2008/10/22 00:00 [revised]
PHST- 2008/11/29 00:00 [accepted]
PHST- 2009/01/13 09:00 [entrez]
PHST- 2009/01/13 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
AID - S1043-4666(08)00803-X [pii]
AID - 10.1016/j.cyto.2008.11.013 [doi]
PST - ppublish
SO  - Cytokine. 2009 Mar;45(3):149-53. doi: 10.1016/j.cyto.2008.11.013. Epub 2009 Jan 
      10.