PMID- 19136944
OWN - NLM
STAT- MEDLINE
DCOM- 20090508
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 458
IP  - 7237
DP  - 2009 Mar 26
TI  - Genetic architecture of mouse skin inflammation and tumour susceptibility.
PG  - 505-8
LID - 10.1038/nature07683 [doi]
AB  - Germline polymorphisms in model organisms and humans influence susceptibility to 
      complex trait diseases such as inflammation and cancer. Mice of the Mus spretus 
      species are resistant to tumour development, and crosses between M. spretus and 
      susceptible Mus musculus strains have been used to map locations of genetic 
      variants that contribute to skin cancer susceptibility. We have integrated 
      germline polymorphisms with gene expression in normal skin from a M. musculus x 
      M. spretus backcross to generate a network view of the gene expression 
      architecture of mouse skin. Here we demonstrate how this approach identifies 
      expression motifs that contribute to tissue organization and biological functions 
      related to inflammation, haematopoiesis, cell cycle control and tumour 
      susceptibility. Motifs associated with inflammation, epidermal barrier function 
      and proliferation are differentially regulated in backcross mice susceptible or 
      resistant to tumour development. The intestinal stem cell marker Lgr5 is 
      identified as a candidate master regulator of the hair follicle, and the vitamin 
      D receptor (Vdr) is linked to coordinated control of epidermal barrier function, 
      inflammation and tumour susceptibility.
FAU - Quigley, David A
AU  - Quigley DA
AD  - Helen Diller Family Comprehensive Cancer Center, University of California San 
      Francisco, San Francisco, California 94115, USA.
FAU - To, Minh D
AU  - To MD
FAU - Perez-Losada, Jesus
AU  - Perez-Losada J
FAU - Pelorosso, Facundo G
AU  - Pelorosso FG
FAU - Mao, Jian-Hua
AU  - Mao JH
FAU - Nagase, Hiroki
AU  - Nagase H
FAU - Ginzinger, David G
AU  - Ginzinger DG
FAU - Balmain, Allan
AU  - Balmain A
LA  - eng
SI  - GEO/GSE12248
GR  - P01 AR050440/AR/NIAMS NIH HHS/United States
GR  - U01 CA084244/CA/NCI NIH HHS/United States
GR  - U01 CA141455/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090111
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Lgr5 protein, mouse)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - Cell Cycle/genetics
MH  - Crosses, Genetic
MH  - Female
MH  - Gene Expression Regulation/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Hair Follicle/metabolism
MH  - Hematopoiesis/genetics
MH  - Inflammation/*genetics/pathology
MH  - Male
MH  - Mice
MH  - Quantitative Trait Loci
MH  - Receptors, Calcitriol/genetics/metabolism
MH  - Receptors, G-Protein-Coupled/genetics/metabolism
MH  - Skin/*metabolism/*pathology
MH  - Skin Neoplasms/*genetics/*pathology
PMC - PMC4460995
MID - NIHMS103031
EDAT- 2009/01/13 09:00
MHDA- 2009/05/09 09:00
PMCR- 2015/06/09
CRDT- 2009/01/13 09:00
PHST- 2008/07/07 00:00 [received]
PHST- 2008/12/08 00:00 [accepted]
PHST- 2009/01/13 09:00 [entrez]
PHST- 2009/01/13 09:00 [pubmed]
PHST- 2009/05/09 09:00 [medline]
PHST- 2015/06/09 00:00 [pmc-release]
AID - nature07683 [pii]
AID - 10.1038/nature07683 [doi]
PST - ppublish
SO  - Nature. 2009 Mar 26;458(7237):505-8. doi: 10.1038/nature07683. Epub 2009 Jan 11.