PMID- 19137022
OWN - NLM
STAT- MEDLINE
DCOM- 20090318
LR  - 20211020
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 28
IP  - 8
DP  - 2009 Feb 26
TI  - Role of chromodomain helicase DNA-binding protein 2 in DNA damage response 
      signaling and tumorigenesis.
PG  - 1053-62
LID - 10.1038/onc.2008.440 [doi]
AB  - The chromodomain helicase DNA-binding proteins (CHDs) are known to affect 
      transcription through their ability to remodel chromatin and modulate histone 
      deacetylation. In an effort to understand the functional role of the CHD2 in 
      mammals, we have generated a Chd2 mutant mouse model. Remarkably, the Chd2 
      protein appears to play a critical role in the development, hematopoiesis and 
      tumor suppression. The Chd2 heterozygous mutant mice exhibit increased 
      extramedullary hematopoiesis and susceptibility to lymphomas. At the cellular 
      level, Chd2 mutants are defective in hematopoietic stem cell differentiation, 
      accumulate higher levels of the chromatin-associated DNA damage response 
      mediator, gamma H2AX, and exhibit an aberrant DNA damage response after X-ray 
      irradiation. Our data suggest a direct role for the chromatin remodeling protein 
      in DNA damage signaling and genome stability maintenance.
FAU - Nagarajan, P
AU  - Nagarajan P
AD  - Department of Biochemistry and Cellular and Molecular Biology, University of 
      Tennessee, Knoxville, TN 37996, USA.
FAU - Onami, T M
AU  - Onami TM
FAU - Rajagopalan, S
AU  - Rajagopalan S
FAU - Kania, S
AU  - Kania S
FAU - Donnell, R
AU  - Donnell R
FAU - Venkatachalam, S
AU  - Venkatachalam S
LA  - eng
GR  - K22 AI057719-01A1/AI/NIAID NIH HHS/United States
GR  - K22 AI057719-02/AI/NIAID NIH HHS/United States
GR  - AI05771901/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090112
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Chd2 protein, mouse)
RN  - 0 (Chromatin)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (H2AX protein, mouse)
RN  - 0 (Histones)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Chromatin/genetics/metabolism
MH  - *DNA Damage
MH  - DNA-Binding Proteins/*physiology
MH  - Fetus
MH  - Hematopoietic Stem Cells/metabolism
MH  - Heterozygote
MH  - Histones/genetics/metabolism
MH  - Liver/metabolism/*pathology
MH  - Lymphoma/genetics/metabolism/*pathology
MH  - Mice
MH  - Mice, Knockout
MH  - *Signal Transduction
MH  - X-Rays
PMC - PMC2648865
MID - NIHMS76746
EDAT- 2009/01/13 09:00
MHDA- 2009/03/19 09:00
PMCR- 2009/08/26
CRDT- 2009/01/13 09:00
PHST- 2009/01/13 09:00 [entrez]
PHST- 2009/01/13 09:00 [pubmed]
PHST- 2009/03/19 09:00 [medline]
PHST- 2009/08/26 00:00 [pmc-release]
AID - onc2008440 [pii]
AID - 10.1038/onc.2008.440 [doi]
PST - ppublish
SO  - Oncogene. 2009 Feb 26;28(8):1053-62. doi: 10.1038/onc.2008.440. Epub 2009 Jan 12.