PMID- 19138574
OWN - NLM
STAT- MEDLINE
DCOM- 20090818
LR  - 20220408
IS  - 1553-4650 (Print)
IS  - 1553-4650 (Linking)
VI  - 16
IP  - 2
DP  - 2009 Mar-Apr
TI  - Feasibility of the use of novel matrix hemostatic sealant (FloSeal) to achieve 
      hemostasis during laparoscopic excision of endometrioma.
PG  - 153-6
LID - 10.1016/j.jmig.2008.11.007 [doi]
AB  - STUDY OBJECTIVE: To evaluate the use of FloSeal, a 2-component (collagen granules 
      and thrombin) topical hemostatic agent for the control of minor bleeding of the 
      ovarian wall at the end of the laparoscopic stripping procedure for 
      endometriomas. DESIGN: Pilot study. SETTING: Tertiary care university hospital. 
      PATIENTS: Twenty consecutive patients who underwent laparoscopic excision of 
      endometriomas were included in the study. INTERVENTIONS: Eight patients was 
      allocated to FloSeal group, whereas the remaining 12 patients were allocated to 
      the control group. MEASUREMENTS AND MAIN RESULTS: At the end of the laparoscopic 
      stripping procedure for ovarian cyst (diameter between 3 and 6 cm), the ovarian 
      cortex was carefully everted and thoroughly rinsed to identify the precise 
      localization of bleeding spots. In the FloSeal group the sites of bleeding were 
      covered with FloSeal under direct vision with a laparoscopic applicator. Gentle 
      pressure on the ovary was applied for 5 minutes and subsequently bleeding sites 
      were reexamined. In the control group hemostasis was obtained with conventional 
      methods. Hemostasis was obtained in all cases by 3 minutes from FloSeal 
      application in both study arms. The time of hemostasis was similar in control and 
      FloSeal groups with a median time of 172 and 182 seconds, respectively. 
      CONCLUSION: This preliminary series suggests that FloSeal may be used instead of 
      bipolar electric coagulation after excision of ovarian endometriomas. Because the 
      latter was identified by some authors as a possible cause of follicular damage, 
      the use of FloSeal for bleeding control should be investigated in patients 
      undergoing laparoscopic stripping of endometriomas.
FAU - Angioli, Roberto
AU  - Angioli R
AD  - Department of Obstetrics and Gynecology at Campus Bio Medico, University of Rome, 
      Italy. r.angioli@unicampus.it
FAU - Muzii, Ludovico
AU  - Muzii L
FAU - Montera, Roberto
AU  - Montera R
FAU - Damiani, Patrizio
AU  - Damiani P
FAU - Bellati, Filippo
AU  - Bellati F
FAU - Plotti, Francesco
AU  - Plotti F
FAU - Zullo, Marzio Angelo
AU  - Zullo MA
FAU - Oronzi, Irma
AU  - Oronzi I
FAU - Terranova, Corrado
AU  - Terranova C
FAU - Panici, Pierluigi Benedetti
AU  - Panici PB
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20090109
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
RN  - 0 (FloSeal Matrix)
RN  - 0 (Hemostatics)
SB  - IM
MH  - Adult
MH  - Endometriosis/*surgery
MH  - Female
MH  - Gelatin Sponge, Absorbable/*therapeutic use
MH  - Gynecologic Surgical Procedures/adverse effects
MH  - Hemostasis, Surgical/*methods
MH  - Hemostatics/*therapeutic use
MH  - Humans
MH  - Laparoscopy/*adverse effects
MH  - Middle Aged
MH  - Ovarian Cysts/*surgery
MH  - Pilot Projects
MH  - Young Adult
EDAT- 2009/01/14 09:00
MHDA- 2009/08/19 09:00
CRDT- 2009/01/14 09:00
PHST- 2008/08/14 00:00 [received]
PHST- 2008/10/24 00:00 [revised]
PHST- 2008/11/06 00:00 [accepted]
PHST- 2009/01/14 09:00 [entrez]
PHST- 2009/01/14 09:00 [pubmed]
PHST- 2009/08/19 09:00 [medline]
AID - S1553-4650(08)01124-2 [pii]
AID - 10.1016/j.jmig.2008.11.007 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2009 Mar-Apr;16(2):153-6. doi: 
      10.1016/j.jmig.2008.11.007. Epub 2009 Jan 9.