PMID- 19139337
OWN - NLM
STAT- MEDLINE
DCOM- 20090130
LR  - 20150417
IS  - 1538-3601 (Electronic)
IS  - 0003-9950 (Linking)
VI  - 127
IP  - 1
DP  - 2009 Jan
TI  - Differentiating optic disc edema from optic nerve head drusen on optical 
      coherence tomography.
PG  - 45-9
LID - 10.1001/archophthalmol.2008.524 [doi]
AB  - OBJECTIVE: To assess optical coherence tomography in differentiating optic disc 
      edema (ODE) due to papilledema and other optic neuropathies from optic nerve head 
      drusen (ONHD). METHODS: Optical coherence tomographic images from 60 subjects (20 
      with ODE, 20 with ONHD, and 20 control subjects) were assessed qualitatively and 
      quantitatively. Qualitative criteria for ODE included an elevated optic nerve 
      head with smooth internal contour and subretinal hyporeflective space (SHYPS) 
      with recumbent "lazy V" pattern. Optic nerve head drusen displayed a 
      "lumpy-bumpy" internal optic nerve contour and a rapid decline in SHYPS 
      thickness. Quantitative comparisons included retinal nerve fiber layer and SHYPS 
      thickness. RESULTS: Optical coherence tomography differentiated ODE from ONHD 
      qualitatively (sensitivity, 63%; specificity, 63%) and quantitatively 
      (sensitivity, 80%; specificity, 90%). Respective differences in mean retinal 
      nerve fiber layer thickness between ODE and ONHD were significant (P < .002) 
      superiorly (206.8 vs 121.7 microm), nasally (176.3 vs 78.6 microm), inferiorly 
      (247.2 vs 153.8 microm), and temporally (180.0 vs 85.5 microm). Respective 
      differences in mean SHYPS thickness between ODE and ONHD were significant (P < 
      .001) at radii of 0.75 mm (512.1 vs 274.4 microm), 1.5 mm (291.4 vs 103.0 
      microm), and 2.0 mm (145.5 vs 60.7 microm). CONCLUSION: Optical coherence 
      tomography can differentiate ODE from ONHD, particularly when the nasal retinal 
      nerve fiber layer and SHYPS thickness at the 2.0-mm radius are greater than 86 
      microm and 127 microm, respectively.
FAU - Johnson, Lenworth N
AU  - Johnson LN
AD  - Neuro-Ophthalmology Unit, Mason Eye Institute, University of Missouri-Columbia, 
      Columbia, MO 65212, USA. johnsonln@health.missouri.edu
FAU - Diehl, Meredith L
AU  - Diehl ML
FAU - Hamm, Chuck W
AU  - Hamm CW
FAU - Sommerville, Drew N
AU  - Sommerville DN
FAU - Petroski, Gregory F
AU  - Petroski GF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Ophthalmol
JT  - Archives of ophthalmology (Chicago, Ill. : 1960)
JID - 7706534
SB  - IM
CIN - Optometry. 2009 Oct;80(10):551. PMID: 20576244
MH  - Diagnosis, Differential
MH  - False Positive Reactions
MH  - Humans
MH  - Nerve Fibers/pathology
MH  - Optic Disk Drusen/*diagnosis
MH  - Papilledema/*diagnosis
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retinal Ganglion Cells/pathology
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
EDAT- 2009/01/14 09:00
MHDA- 2009/01/31 09:00
CRDT- 2009/01/14 09:00
PHST- 2009/01/14 09:00 [entrez]
PHST- 2009/01/14 09:00 [pubmed]
PHST- 2009/01/31 09:00 [medline]
AID - 127/1/45 [pii]
AID - 10.1001/archophthalmol.2008.524 [doi]
PST - ppublish
SO  - Arch Ophthalmol. 2009 Jan;127(1):45-9. doi: 10.1001/archophthalmol.2008.524.