PMID- 19141606
OWN - NLM
STAT- MEDLINE
DCOM- 20090518
LR  - 20220331
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 160
IP  - 5
DP  - 2009 May
TI  - Studies of insulin resistance in patients with clinical and subclinical 
      hypothyroidism.
PG  - 785-90
LID - 10.1530/EJE-08-0797 [doi]
AB  - OBJECTIVE: Although clinical hypothyroidism (HO) is associated with insulin 
      resistance, there is no information on insulin action in subclinical 
      hypothyroidism (SHO). DESIGN AND METHODS: To investigate this, we assessed the 
      sensitivity of glucose metabolism to insulin both in vivo (by an oral glucose 
      tolerance test) and in vitro (by measuring insulin-stimulated rates of glucose 
      transport in isolated monocytes with flow cytometry) in 21 euthyroid subjects 
      (EU), 12 patients with HO, and 13 patients with SHO. RESULTS: All three groups 
      had comparable plasma glucose levels, with the HO and SHO having higher plasma 
      insulin than the EU (P<0.05). Homeostasis model assessment index was increased in 
      HO (1.97+/-0.22) and SHO (1.99+/-0.13) versus EU (1.27+/-0.16, P<0.05), while 
      Matsuda index was decreased in HO (3.89+/-0.36) and SHO (4.26+/-0.48) versus EU 
      (7.76+/-0.87, P<0.001), suggesting insulin resistance in both fasting and 
      post-glucose state. At 100 microU/ml insulin: i) GLUT4 levels on the monocyte 
      plasma membrane were decreased in both HO (215+/-19 mean fluorescence intensity, 
      MFI) and SHO (218+/-24 MFI) versus EU (270+/-25 MFI, P=0.03 and 0.04 
      respectively), and ii) glucose transport rates in monocytes from HO (481+/-30 
      MFI) and SHO (462+/-19 MFI) were decreased versus EU (571+/-15 MFI, P=0.04 and 
      0.004 respectively). CONCLUSIONS: In patients with HO and SHO: i) insulin 
      resistance was comparable; ii) insulin-stimulated rates of glucose transport in 
      isolated monocytes were decreased due to impaired translocation of GLUT4 glucose 
      transporters on the plasma membrane; iii) these findings could justify the 
      increased risk for insulin resistance-associated disorders, such as 
      cardiovascular disease, observed in patients with HO or SHO.
FAU - Maratou, Eirini
AU  - Maratou E
AD  - Hellenic National Center for Research, Prevention and Treatment of Diabetes 
      Mellitus and its Complications (HNDC), GR-10675 Athens, Greece.
FAU - Hadjidakis, Dimitrios J
AU  - Hadjidakis DJ
FAU - Kollias, Anastasios
AU  - Kollias A
FAU - Tsegka, Katerina
AU  - Tsegka K
FAU - Peppa, Melpomeni
AU  - Peppa M
FAU - Alevizaki, Maria
AU  - Alevizaki M
FAU - Mitrou, P
AU  - Mitrou P
FAU - Lambadiari, V
AU  - Lambadiari V
FAU - Boutati, Eleni
AU  - Boutati E
FAU - Nikzas, Daniel
AU  - Nikzas D
FAU - Tountas, Nikolaos
AU  - Tountas N
FAU - Economopoulos, Theofanis
AU  - Economopoulos T
FAU - Raptis, Sotirios A
AU  - Raptis SA
FAU - Dimitriadis, George
AU  - Dimitriadis G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090113
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 3)
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Insulin)
RN  - 0 (SLC2A3 protein, human)
RN  - 0 (SLC2A4 protein, human)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cell Membrane/metabolism
MH  - Cells, Cultured
MH  - Fasting/blood
MH  - Glucose Tolerance Test
MH  - Glucose Transporter Type 3/metabolism
MH  - Glucose Transporter Type 4/metabolism
MH  - Humans
MH  - Hypothyroidism/blood/*metabolism/pathology
MH  - Insulin/blood/metabolism
MH  - Insulin Resistance/*physiology
MH  - Middle Aged
MH  - Monocytes/metabolism/pathology
MH  - Thyroid Function Tests
EDAT- 2009/01/15 09:00
MHDA- 2009/05/19 09:00
CRDT- 2009/01/15 09:00
PHST- 2009/01/15 09:00 [entrez]
PHST- 2009/01/15 09:00 [pubmed]
PHST- 2009/05/19 09:00 [medline]
AID - EJE-08-0797 [pii]
AID - 10.1530/EJE-08-0797 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2009 May;160(5):785-90. doi: 10.1530/EJE-08-0797. Epub 2009 Jan 
      13.