PMID- 1914272
OWN - NLM
STAT- MEDLINE
DCOM- 19911105
LR  - 20190510
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 14
IP  - 8
DP  - 1991 Aug
TI  - A large-scale trial of captopril for mild to moderate heart failure in the 
      primary care setting.
PG  - 676-82
AB  - A large-scale, prospective, 8-week, office-based study was conducted to evaluate 
      the effects of adding captopril to a therapeutic regimen of diuretic and digoxin 
      or diuretic alone in the management of patients with mild to moderate congestive 
      heart failure (CHF). A total of 2218 primary care physicians evaluated 6669 
      patients over the study period for efficacy parameters, which included changes in 
      a modified New York Heart Association (NYHA) functional classification, 
      symptomatology, and daily activity levels. Overall, 63.8% of evaluated patients 
      improved with regard to functional ability, with 19% improving two or more 
      modified NYHA classes. Symptoms of CHF, including dyspnea on exertion, fatigue, 
      and orthopnea and signs, including rales and peripheral edema, were reduced in 
      86% of these patients: 41.5% demonstrated mild improvement; 30.0%, moderate 
      improvement; and 14.5%, marked improvement. Three parameters, with which patients 
      reported having difficulty at study entry, were assessed serially to evaluate 
      changes in functional capacity; 78.5% of patients reported an increased walking 
      distance, 72.3% had increased capacity for climbing stairs, and 60.2% had 
      improved capacity for individual recreational activities. Adverse experiences 
      were reported in 18.1% of all patients; 4.9% of patients withdrew from the study 
      because of an adverse effect. Combination therapy with captopril and diuretic for 
      CHF was shown to be safe and effective regardless of patient age (less than 70 
      years vs. greater than or equal to 70 years), duration of heart failure (less 
      than 1 year vs. greater than 1 year), presence of digoxin treatment, or the 
      dosing schedule employed.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - DiBianco, R
AU  - DiBianco R
AD  - Cardiology Research, Washington Adventist Hospital, Tacoma Park, MD 20912.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Diuretics)
RN  - 73K4184T59 (Digoxin)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Captopril/administration & dosage/adverse effects/*therapeutic use
MH  - Digoxin/therapeutic use
MH  - Diuretics/therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Heart Failure/classification/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Office Visits
MH  - *Physicians, Family
MH  - Prospective Studies
MH  - Walking
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1002/clc.4960140810 [doi]
PST - ppublish
SO  - Clin Cardiol. 1991 Aug;14(8):676-82. doi: 10.1002/clc.4960140810.