PMID- 19143120
OWN - NLM
STAT- MEDLINE
DCOM- 20090202
LR  - 20130502
IS  - 1110-0583 (Print)
IS  - 1110-0583 (Linking)
VI  - 38
IP  - 1
DP  - 2008 Apr
TI  - Kinetics of eosinophilia and IgE production in experimental murine toxocariasis.
PG  - 53-64
AB  - Eosinophilia and immunoglobulin E (IgE) antibody are considered the first and 
      important elements in host responses to helminth infection. Toxocara canis, which 
      elicits prominent eosinophilia and IgE production in normal mice, may be useful 
      in understanding the kinetics of circulating peripheral blood eosinophils and IgE 
      antibody during infection. The onset, magnitude and duration of peripheral blood 
      eosinophilia and total IgE production after primary T. canis infection in female 
      outbred albino mice was investigated. Mice were either sham inoculated (controls) 
      or were orally infected with 1000 embryonated eggs of T. canis. Patterns in 
      leucocytic changes include significant increase in total WBC count between weeks 
      6 and 13 post infection (PI) with a peak on week 8 PI. Mice showed eosinophilia 
      between weeks 2 to 17 PI with a peak on week 7. The development of eosinophilia 
      in T. canis-infected mice was accompanied by the release of prominent level of 
      serum IgE between weeks 2 to 21 with a peak at week 6 PI. These findings showed 
      that eosinophilia in T. canis infected outbred mice can be T-cell dependent.
FAU - Elsheikha, Hany M
AU  - Elsheikha HM
AD  - Department of Parasitology, Faculty of Veterinary Medicine, Mansoura University, 
      Mansoura 35516, Egypt.
FAU - El-Beshbishi, Samar N
AU  - El-Beshbishi SN
FAU - El-Shazly, Atef M
AU  - El-Shazly AM
FAU - Hafez, Adel O
AU  - Hafez AO
FAU - Morsy, Tosson A
AU  - Morsy TA
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - J Egypt Soc Parasitol
JT  - Journal of the Egyptian Society of Parasitology
JID - 8102141
RN  - 0 (Antigens, Helminth)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/immunology
MH  - Eosinophilia/etiology/*immunology
MH  - Female
MH  - Immunoglobulin E/blood/*immunology
MH  - Mice
MH  - Random Allocation
MH  - Time Factors
MH  - *Toxocara canis
MH  - Toxocariasis/complications/*immunology
EDAT- 2009/01/16 09:00
MHDA- 2009/02/03 09:00
CRDT- 2009/01/16 09:00
PHST- 2009/01/16 09:00 [entrez]
PHST- 2009/01/16 09:00 [pubmed]
PHST- 2009/02/03 09:00 [medline]
PST - ppublish
SO  - J Egypt Soc Parasitol. 2008 Apr;38(1):53-64.