PMID- 19144857
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20220310
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 2
DP  - 2009 Jan 14
TI  - Complementary actions of BDNF and neurotrophin-3 on the firing patterns and 
      synaptic composition of motoneurons.
PG  - 575-87
LID - 10.1523/JNEUROSCI.5312-08.2009 [doi]
AB  - Neurotrophins, as target-derived factors, are essential for neuronal survival 
      during development, but during adulthood, their scope of actions widens to become 
      also mediators of synaptic and morphological plasticity. Target disconnection by 
      axotomy produces an initial synaptic stripping ensued by synaptic rearrangement 
      upon target reinnervation. Using abducens motoneurons of the oculomotor system as 
      a model for axotomy, we report that trophic support by brain-derived neurotrophic 
      factor (BDNF), neurotrophin-3 (NT-3) or a mixture of both, delivered to the stump 
      of severed axons, results in either the prevention of synaptic stripping when 
      administered immediately after lesion or in a promotion of reinnervation of 
      afferents to abducens motoneurons once synaptic stripping had occurred, in 
      concert with the recovery of synaptic potentials evoked from the vestibular 
      nerve. Synaptotrophic effects, however, were larger when both neurotrophins were 
      applied together. The axotomy-induced reduction in firing sensitivities related 
      to eye movements were also restored to normal values when BDNF and NT-3 were 
      administered, but discharge characteristics recovered in a complementary manner 
      when only one neurotrophin was used. This is the first report to show selective 
      retrograde trophic dependence of circuit-driven firing properties in vivo 
      indicating that NT-3 restored the phasic firing, whereas BDNF supported the tonic 
      firing of motoneurons during eye movement performance. Therefore, our data report 
      a link between the synaptotrophic actions of neurotrophins, retrogradely 
      delivered, and the alterations of neuronal firing patterns during motor 
      behaviors. These trophic actions could be responsible, in part, for synaptic 
      rearrangements that alter circuit stability and synaptic balance during plastic 
      events of the brain.
FAU - Davis-Lopez de Carrizosa, Maria A
AU  - Davis-Lopez de Carrizosa MA
AD  - Departamento de Fisiologia y Zoologia, Facultad de Biologia, Universidad de 
      Sevilla, Sevilla, Spain.
FAU - Morado-Diaz, Camilo J
AU  - Morado-Diaz CJ
FAU - Tena, Juan J
AU  - Tena JJ
FAU - Benitez-Temino, Beatriz
AU  - Benitez-Temino B
FAU - Pecero, Maria L
AU  - Pecero ML
FAU - Morcuende, Sara R
AU  - Morcuende SR
FAU - de la Cruz, Rosa R
AU  - de la Cruz RR
FAU - Pastor, Angel M
AU  - Pastor AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Synaptophysin)
RN  - 0 (Vesicular Glutamate Transport Proteins)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Analysis of Variance
MH  - Animals
MH  - Axotomy/methods
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Carbazoles/pharmacology
MH  - Cats
MH  - Choline O-Acetyltransferase/metabolism
MH  - Drug Interactions
MH  - Electric Stimulation/methods
MH  - Enzyme Inhibitors/pharmacology
MH  - Eye Movements/drug effects
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Indole Alkaloids/pharmacology
MH  - Motor Neurons/*drug effects/metabolism
MH  - Nerve Regeneration/drug effects
MH  - Neurotrophin 3/*pharmacology
MH  - Pons/cytology
MH  - Synaptic Potentials/drug effects
MH  - Synaptic Transmission/*drug effects
MH  - Synaptophysin/metabolism
MH  - Time Factors
MH  - Vesicular Glutamate Transport Proteins/metabolism
PMC - PMC6664940
EDAT- 2009/01/16 09:00
MHDA- 2009/04/09 09:00
PMCR- 2009/07/14
CRDT- 2009/01/16 09:00
PHST- 2009/01/16 09:00 [entrez]
PHST- 2009/01/16 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2009/07/14 00:00 [pmc-release]
AID - 29/2/575 [pii]
AID - 3444240 [pii]
AID - 10.1523/JNEUROSCI.5312-08.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Jan 14;29(2):575-87. doi: 10.1523/JNEUROSCI.5312-08.2009.