PMID- 19144988
OWN - NLM
STAT- MEDLINE
DCOM- 20090410
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 113
IP  - 9
DP  - 2009 Feb 26
TI  - Plasmacytoid dendritic cells prime alloreactive T cells to mediate 
      graft-versus-host disease as antigen-presenting cells.
PG  - 2088-95
LID - 10.1182/blood-2008-07-168609 [doi]
AB  - Dendritic cells (DCs) can be classified into 2 distinct subsets: conventional DCs 
      (cDCs) and plasmacytoid DCs (pDCs). cDCs can prime antigen-specific T-cell 
      immunity, whereas in vivo function of pDCs as antigen-presenting cells remains 
      controversial. We evaluated the contribution of pDCs to allogeneic T-cell 
      responses in vivo in mouse models of graft-versus-host disease (GVHD) after 
      allogeneic hematopoietic stem cell transplantation by an add-back study of 
      MHC-expressing pDCs into major histocompatibility complex-deficient mice that 
      were resistant to GVHD. Alloantigen expression on pDCs alone was sufficient to 
      prime alloreactive T cells and cause GVHD. An inflammatory environment created by 
      host irradiation has the decisive role in maturing pDCs for T-cell priming but 
      this process does not require Toll-like receptor signaling. Thus, functional 
      outcomes of pDC-T-cell interactions depend on the immunologic context of 
      encounter. To our knowledge, these results are the first to directly demonstrate 
      an in vivo pathogenic role of pDCs as antigen-presenting cells in an 
      antigen-specific T cell-mediated disease in the absence of other DC subsets and 
      to provide important insight into developing strategies for tolerance induction 
      in transplantation.
FAU - Koyama, Motoko
AU  - Koyama M
AD  - Department of Medicine and Biosystemic Science, Kyushu University Graduate School 
      of Medical Science, Fukuoka, Japan.
FAU - Hashimoto, Daigo
AU  - Hashimoto D
FAU - Aoyama, Kazutoshi
AU  - Aoyama K
FAU - Matsuoka, Ken-ichi
AU  - Matsuoka K
FAU - Karube, Kennosuke
AU  - Karube K
FAU - Niiro, Hiroaki
AU  - Niiro H
FAU - Harada, Mine
AU  - Harada M
FAU - Tanimoto, Mitsune
AU  - Tanimoto M
FAU - Akashi, Koichi
AU  - Akashi K
FAU - Teshima, Takanori
AU  - Teshima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090114
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
CIN - Blood. 2009 Jun 4;113(23):6038-9. PMID: 19498034
MH  - Animals
MH  - Antigen Presentation/physiology
MH  - Antigen-Presenting Cells/immunology/*physiology
MH  - Autoimmunity/immunology
MH  - CD4-Positive T-Lymphocytes/pathology
MH  - CD8-Positive T-Lymphocytes/pathology
MH  - Dendritic Cells/immunology/pathology/*physiology
MH  - Female
MH  - Genes, MHC Class II
MH  - Graft vs Host Disease/*etiology/immunology/pathology
MH  - Lymphocyte Activation/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - T-Lymphocytes/*immunology/pathology
EDAT- 2009/01/16 09:00
MHDA- 2009/04/11 09:00
CRDT- 2009/01/16 09:00
PHST- 2009/01/16 09:00 [entrez]
PHST- 2009/01/16 09:00 [pubmed]
PHST- 2009/04/11 09:00 [medline]
AID - S0006-4971(20)37652-7 [pii]
AID - 10.1182/blood-2008-07-168609 [doi]
PST - ppublish
SO  - Blood. 2009 Feb 26;113(9):2088-95. doi: 10.1182/blood-2008-07-168609. Epub 2009 
      Jan 14.