PMID- 19146581
OWN - NLM
STAT- MEDLINE
DCOM- 20090410
LR  - 20211203
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 18
IP  - 2
DP  - 2009 Feb
TI  - Molecular pathways involved in hair follicle tumor formation: all about mammalian 
      target of rapamycin?
PG  - 185-91
LID - 10.1111/j.1600-0625.2008.00808.x [doi]
AB  - Hair follicle tumors show a broad range of phenotypic variability and diverse 
      histopathological characteristics. To date, different genes and signalling 
      cascades have been implicated in the development and growth of these tumors 
      including the sonic hedgehog, nuclear factor kappa-B and wingless pathway. While 
      the former three have received ample attention, little is known about the 
      possible role of mammalian target of rapamycin (mTOR) in trichofollicular 
      tumorigenesis. Here, we delineate how mTOR can link the various signalling 
      pathways, thereby proposing a unifying model for hair follicle tumor formation.
FAU - van Steensel, Maurice A M
AU  - van Steensel MA
AD  - Department of Dermatology, University Medical Centre Maastricht, University 
      Hospital Maastricht, Maastricht, The Netherlands. mvst@sder.azm.nl
FAU - van Geel, Michel
AU  - van Geel M
FAU - Badeloe, Sadhanna
AU  - Badeloe S
FAU - Poblete-Gutierrez, Pamela
AU  - Poblete-Gutierrez P
FAU - Frank, Jorge
AU  - Frank J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Hedgehog Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Wnt Proteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Hair Follicle
MH  - Hedgehog Proteins/physiology
MH  - Humans
MH  - NF-kappa B/physiology
MH  - Protein Kinases/*physiology
MH  - Signal Transduction/*physiology
MH  - Skin Neoplasms/*physiopathology
MH  - TOR Serine-Threonine Kinases
MH  - Wnt Proteins/physiology
EDAT- 2009/01/17 09:00
MHDA- 2009/04/11 09:00
CRDT- 2009/01/17 09:00
PHST- 2009/01/17 09:00 [entrez]
PHST- 2009/01/17 09:00 [pubmed]
PHST- 2009/04/11 09:00 [medline]
AID - EXD808 [pii]
AID - 10.1111/j.1600-0625.2008.00808.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2009 Feb;18(2):185-91. doi: 10.1111/j.1600-0625.2008.00808.x.