PMID- 19146670
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20211020
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 10
DP  - 2009 Jan 15
TI  - The relationship between magnetic and electrophysiological responses to complex 
      tactile stimuli.
PG  - 4
LID - 10.1186/1471-2202-10-4 [doi]
AB  - BACKGROUND: Magnetoencephalography (MEG) has become an increasingly popular 
      technique for non-invasively characterizing neuromagnetic field changes in the 
      brain at a high temporal resolution. To examine the reliability of the MEG 
      signal, we compared magnetic and electrophysiological responses to complex 
      natural stimuli from the same animals. We examined changes in neuromagnetic 
      fields, local field potentials (LFP) and multi-unit activity (MUA) in macaque 
      monkey primary somatosensory cortex that were induced by varying the rate of 
      mechanical stimulation. Stimuli were applied to the fingertips with three 
      inter-stimulus intervals (ISIs): 0.33s, 1s and 2s. RESULTS: Signal intensity was 
      inversely related to the rate of stimulation, but to different degrees for each 
      measurement method. The decrease in response at higher stimulation rates was 
      significantly greater for MUA than LFP and MEG data, while no significant 
      difference was observed between LFP and MEG recordings. Furthermore, response 
      latency was the shortest for MUA and the longest for MEG data. CONCLUSION: The 
      MEG signal is an accurate representation of electrophysiological responses to 
      complex natural stimuli. Further, the intensity and latency of the MEG signal 
      were better correlated with the LFP than MUA data suggesting that the MEG signal 
      reflects primarily synaptic currents rather than spiking activity. These 
      differences in latency could be attributed to differences in the extent of 
      spatial summation and/or differential laminar sensitivity.
FAU - Zhu, Zhao
AU  - Zhu Z
AD  - Biomagnetic Imaging Laboratory, Department of Radiology, University of California 
      San Francisco, San Francisco, CA 94143-0628, USA. zhaozhu@radiology.ucsf.edu
FAU - Zumer, Johanna M
AU  - Zumer JM
FAU - Lowenthal, Marianne E
AU  - Lowenthal ME
FAU - Padberg, Jeff
AU  - Padberg J
FAU - Recanzone, Gregg H
AU  - Recanzone GH
FAU - Krubitzer, Leah A
AU  - Krubitzer LA
FAU - Nagarajan, Srikantan S
AU  - Nagarajan SS
FAU - Disbrow, Elizabeth A
AU  - Disbrow EA
LA  - eng
GR  - R01 NS044590/NS/NINDS NIH HHS/United States
GR  - R01 NS35103/NS/NINDS NIH HHS/United States
GR  - R01 NS035103/NS/NINDS NIH HHS/United States
GR  - R01 DC006435-05/DC/NIDCD NIH HHS/United States
GR  - R01 DC004855/DC/NIDCD NIH HHS/United States
GR  - R01 DC006435/DC/NIDCD NIH HHS/United States
GR  - R01 DC004855-07/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090115
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Macaca
MH  - Magnetoencephalography/*methods
MH  - Male
MH  - Microelectrodes
MH  - Physical Stimulation
MH  - Reaction Time
MH  - Regression Analysis
MH  - Somatosensory Cortex/*physiology
MH  - Touch Perception/*physiology
PMC - PMC2652466
EDAT- 2009/01/17 09:00
MHDA- 2009/04/10 09:00
PMCR- 2009/01/15
CRDT- 2009/01/17 09:00
PHST- 2008/07/02 00:00 [received]
PHST- 2009/01/15 00:00 [accepted]
PHST- 2009/01/17 09:00 [entrez]
PHST- 2009/01/17 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
PHST- 2009/01/15 00:00 [pmc-release]
AID - 1471-2202-10-4 [pii]
AID - 10.1186/1471-2202-10-4 [doi]
PST - epublish
SO  - BMC Neurosci. 2009 Jan 15;10:4. doi: 10.1186/1471-2202-10-4.