PMID- 19146937
OWN - NLM
STAT- MEDLINE
DCOM- 20090519
LR  - 20171116
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 122
IP  - 2
DP  - 2009 Mar 18
TI  - Nephro-protective effect of Kangqianling decoction on chronic renal failure rats.
PG  - 367-73
LID - 10.1016/j.jep.2008.12.018 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Kangqianling decoction (KQL), the modified 
      formulation of a classical Chinese prescription named Taohongsiwu decoction, was 
      clinically employed to treat renal fibrosis in chronic renal failure. AIM OF THE 
      STUDY: The present study was designed to examine whether KQL has a protective 
      effect on renal function in association with transforming growth factor-beta 
      (TGF-beta), angiotensin II (Ang II), tumor necrosis factor-alpha (TNF-alpha), 
      nuclear factor-kappaB (NF-kappaB) in rats with 5/6 renal ablation (Nx)-induced 
      chronic renal failure. RESULTS: In renal function deterioration progression, the 
      high expression of serum creatinine (Scr), 24-h urine protein and systolic blood 
      pressure were markedly (P<0.05 or P<0.01) restored by KQL, respectively, at 4 and 
      8 weeks. The increasing expressions of renal Ang II (P<0.05), angiotensin 
      II1-receptor (AT1R) (P<0.05), TNF-alpha (P<0.05), NF-kappaB (P<0.001) and urine 
      TGF-beta1 (P<0.05) were reduced by the treatment of KQL. Immunohistochemical 
      study further confirmed the nephro-protective activity of KQL as compared to the 
      control and Sham group. CONCLUSIONS: The results indicate that KQL is able to 
      protect renal function via ameliorating experimental rat renal failure as found 
      in these renal functional parameters.
FAU - He, Liqun
AU  - He L
AD  - Traditional Chinese internal medicine E-institute of Shanghai University 
      (Shanghai TCM University), Nephropathy Department, ShuGuang Hospital, Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Shen, Peicheng
AU  - Shen P
FAU - Fu, Qiang
AU  - Fu Q
FAU - Li, Jun
AU  - Li J
FAU - Dan, Mo
AU  - Dan M
FAU - Wang, Xiaoyan
AU  - Wang X
FAU - Jia, Wei
AU  - Jia W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081225
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (kangxianling)
RN  - 11128-99-7 (Angiotensin II)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Angelica sinensis
MH  - Angiotensin II/metabolism
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Blood Urea Nitrogen
MH  - Creatinine/blood
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Kidney/*drug effects/pathology
MH  - Kidney Failure, Chronic/*drug therapy/pathology
MH  - *Magnoliopsida
MH  - NF-kappa B/metabolism
MH  - Proteins/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Angiotensin, Type 1/metabolism
MH  - Salvia miltiorrhiza
MH  - Transforming Growth Factor beta1/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Ziziphus
EDAT- 2009/01/17 09:00
MHDA- 2009/05/20 09:00
CRDT- 2009/01/17 09:00
PHST- 2007/09/17 00:00 [received]
PHST- 2008/11/21 00:00 [revised]
PHST- 2008/12/16 00:00 [accepted]
PHST- 2009/01/17 09:00 [entrez]
PHST- 2009/01/17 09:00 [pubmed]
PHST- 2009/05/20 09:00 [medline]
AID - S0378-8741(08)00694-6 [pii]
AID - 10.1016/j.jep.2008.12.018 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2009 Mar 18;122(2):367-73. doi: 10.1016/j.jep.2008.12.018. Epub 
      2008 Dec 25.