PMID- 19147047
OWN - NLM
STAT- MEDLINE
DCOM- 20090204
LR  - 20151119
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 53
IP  - 3
DP  - 2009 Jan 20
TI  - Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic 
      resonance in different forms of left ventricular hypertrophy relation to 
      remodeling.
PG  - 284-91
LID - 10.1016/j.jacc.2008.08.064 [doi]
AB  - OBJECTIVES: We aimed to evaluate the incidence and patterns of late gadolinium 
      enhancement (LGE) in different forms of left ventricular hypertrophy (LVH) and to 
      determine their relation to severity of left ventricular (LV) remodeling. 
      BACKGROUND: Left ventricular hypertrophy is an independent predictor of cardiac 
      mortality. The relationship between LVH and myocardial fibrosis as defined by LGE 
      cardiovascular magnetic resonance (CMR) is not well understood. METHODS: A total 
      of 440 patients with aortic stenosis (AS), arterial hypertension (AH), or 
      hypertrophic cardiomyopathy (HCM) fulfilling echo criteria of LVH underwent CMR 
      with assessment of LV size, weight, function, and LGE. Patients with increased 
      left ventricular mass index (LVMI) resulting in global LVH in CMR were included 
      in the study. RESULTS: Criteria were fulfilled by 83 patients (56 men, age 57 +/- 
      14 years; AS, n = 21; AH, n = 26; HCM, n = 36). Late gadolinium enhancement was 
      present in all forms of LVH (AS: 62%, AH: 50%; HCM: 72%, p = NS) and was 
      correlated with LVMI (r = 0.237, p = 0.045). There was no significant 
      relationship between morphological obstruction and LGE. The AS subjects with LGE 
      showed higher LV end-diastolic volumes than those without (1.0 +/- 0.2 ml/cm vs. 
      0.8 +/- 0.2 ml/cm, p < 0.015). Typical patterns of LGE were observed in HCM but 
      not in AS and AH. CONCLUSIONS: Fibrosis as detected by CMR is a frequent feature 
      of LVH, regardless of its cause, and depends on the severity of LV remodeling. As 
      LGE emerges as a useful tool for risk stratification also in nonischemic heart 
      diseases, our findings have the potential to individualize treatment strategies.
FAU - Rudolph, Andre
AU  - Rudolph A
AD  - Franz-Volhard-Klinik, Charite Campus Buch, HELIOS-Kliniken Berlin, 
      Universitatsmedizin Berlin, Berlin, Germany.
FAU - Abdel-Aty, Hassan
AU  - Abdel-Aty H
FAU - Bohl, Steffen
AU  - Bohl S
FAU - Boye, Philipp
AU  - Boye P
FAU - Zagrosek, Anja
AU  - Zagrosek A
FAU - Dietz, Rainer
AU  - Dietz R
FAU - Schulz-Menger, Jeanette
AU  - Schulz-Menger J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - J Am Coll Cardiol. 2009 Jan 20;53(3):292-4. PMID: 19147048
MH  - Adult
MH  - Aged
MH  - Aortic Valve Stenosis/diagnosis/mortality
MH  - Cardiomyopathy, Hypertrophic/diagnosis/mortality
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Female
MH  - Fibrosis/pathology
MH  - Follow-Up Studies
MH  - Gadolinium
MH  - Heart Function Tests
MH  - Humans
MH  - Hypertension/diagnosis/mortality
MH  - Hypertrophy, Left Ventricular/*diagnosis/*mortality
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Ventricular Remodeling/*physiology
EDAT- 2009/01/17 09:00
MHDA- 2009/02/05 09:00
CRDT- 2009/01/17 09:00
PHST- 2008/05/05 00:00 [received]
PHST- 2008/07/24 00:00 [revised]
PHST- 2008/08/12 00:00 [accepted]
PHST- 2009/01/17 09:00 [entrez]
PHST- 2009/01/17 09:00 [pubmed]
PHST- 2009/02/05 09:00 [medline]
AID - S0735-1097(08)03306-8 [pii]
AID - 10.1016/j.jacc.2008.08.064 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2009 Jan 20;53(3):284-91. doi: 10.1016/j.jacc.2008.08.064.