PMID- 19147457
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20110608
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 11
IP  - 1
DP  - 2009 Jan
TI  - Heart rate per se impacts cardiac function in patients with systolic heart 
      failure and pacing: a pilot study.
PG  - 53-7
LID - 10.1093/eurjhf/hfn016 [doi]
AB  - AIMS: This study was designed to compare the specific effects of two heart rates 
      (HR), 55 and 75 b.p.m., in patients with heart failure (HF). METHODS AND RESULTS: 
      Patients with chronic HF, left ventricular ejection fraction (LVEF) </= 35%, and 
      a pacemaker with >90% of paced QRS, were included in a randomized cross-over 
      trial of two 3-month periods where pacing rate was set at either 55 or 75 b.p.m. 
      At the end of each period, patients were examined and radionuclide 
      ventriculography, echocardiography, and blood sampling were performed for 
      centralized and blinded analysis. Two patients did not complete the study because 
      of early worsening while paced at 75 b.p.m. Twelve patients completed the study. 
      Compared with 75 b.p.m., pacing at 55 b.p.m. was associated with a higher LVEF 
      [+4.7% (2.6-6.7), P < 0.001], lower B-type natriuretic peptide levels [-91 pg/mL 
      (-148 to -33), P < 0.01], lower systolic pulmonary artery pressure (41 +/- 10 vs. 
      47 +/- 10 mmHg, P = 0.02) and lower NYHA (New York Heart Association) class (2.2 
      +/- 0.6 vs. 2.6 +/- 0.5, P = 0.03). The baseline pacing rate prior to inclusion 
      had no effect on results. CONCLUSION: HR per se may impact cardiac function and 
      low HR might be beneficial in patients with systolic HF compared with 
      intermediate HR.
FAU - Logeart, Damien
AU  - Logeart D
AD  - Hopital Lariboisiere, Cardiology Department, Assistance Publique - Hopitaux de 
      Paris, Paris, France. damien.logeart@lrb.aphp.fr
FAU - Gueffet, Jean-Pierre
AU  - Gueffet JP
FAU - Rouzet, Francois
AU  - Rouzet F
FAU - Pousset, Francoise
AU  - Pousset F
FAU - Chavelas, Christophe
AU  - Chavelas C
FAU - Solal, Alain Cohen
AU  - Solal AC
FAU - Jondeau, Guillaume
AU  - Jondeau G
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Cardiac Pacing, Artificial
MH  - Chronic Disease
MH  - Cross-Over Studies
MH  - Female
MH  - Heart Failure, Systolic/diagnosis/*physiopathology/therapy
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Pilot Projects
MH  - Radionuclide Ventriculography
MH  - Stroke Volume
MH  - Ventricular Function, Left/physiology
EDAT- 2009/01/17 09:00
MHDA- 2009/03/20 09:00
CRDT- 2009/01/17 09:00
PHST- 2009/01/17 09:00 [entrez]
PHST- 2009/01/17 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
AID - hfn016 [pii]
AID - 10.1093/eurjhf/hfn016 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2009 Jan;11(1):53-7. doi: 10.1093/eurjhf/hfn016.