PMID- 19147739
OWN - NLM
STAT- MEDLINE
DCOM- 20090429
LR  - 20220330
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Print)
IS  - 0002-0729 (Linking)
VI  - 38
IP  - 2
DP  - 2009 Mar
TI  - Heart rate variability and its changes over 5 years in older adults.
PG  - 212-8
LID - 10.1093/ageing/afn292 [doi]
AB  - PURPOSE: to characterise the association between age, ageing and heart rate 
      variability (HRV) in older individuals, 585 adults age >65 years with two 24-h 
      Holter recordings in the Cardiovascular Health Study were studied. METHODS: heart 
      rate (HR), ventricular premature contractions (VPCs), atrial premature 
      contractions (APCs), frequency-domain, ratio-based and non-linear HRV and heart 
      rate turbulence (HRT) were examined cross-sectionally by 5-year age groups and 
      prospectively over 5 years. Analyses adjusted for gender, lower versus elevated 
      cardiovascular (CV) risk and for the change in CV risk. RESULTS: HR declined, and 
      VPCs and APCs increased per 5-year increase in age. Frequency-domain HRV 
      decreased more at 65-69, less at 70-74 and minimally at > or =75 years, 
      independent of CVD risk or change in CVD risk. Ratio and non-linear HRV continued 
      to decline to > or =75 years old. Ratio HRV and HRT slope were more strongly 
      related to CVD risk than frequency-domain HRV. CONCLUSIONS: cardiac autonomic 
      function, assessed by frequency-domain HRV, declines most at 65-70 and levels off 
      at age >75. The decline is independent of CVD risk or change in CVD risk. 
      Ratio-based and non-linear HRV and HRT slope continued to change with increasing 
      age and were more closely related to CVD risk than frequency-domain HRV.
FAU - Stein, Phyllis K
AU  - Stein PK
AD  - Washington University School of Medicine, St Louis, MO, USA. pstein@im.wustl.edu
FAU - Barzilay, Joshua I
AU  - Barzilay JI
FAU - Chaves, Paulo H M
AU  - Chaves PH
FAU - Domitrovich, Peter P
AU  - Domitrovich PP
FAU - Gottdiener, John S
AU  - Gottdiener JS
LA  - eng
GR  - U01 HL080295/HL/NHLBI NIH HHS/United States
GR  - N01 HC015103/HC/NHLBI NIH HHS/United States
GR  - N01HC55222/HL/NHLBI NIH HHS/United States
GR  - N01 HC-55222/HC/NHLBI NIH HHS/United States
GR  - R01 HL062181/HL/NHLBI NIH HHS/United States
GR  - N01-HC-75150/HC/NHLBI NIH HHS/United States
GR  - N01HC75150/HL/NHLBI NIH HHS/United States
GR  - N01-HC-85079/HC/NHLBI NIH HHS/United States
GR  - N01HC85079/HL/NHLBI NIH HHS/United States
GR  - N01 HC045133/HC/NHLBI NIH HHS/United States
GR  - N01 HC035129/HC/NHLBI NIH HHS/United States
GR  - R0-1 HL62181/HL/NHLBI NIH HHS/United States
GR  - N01-HC-85086/HC/NHLBI NIH HHS/United States
GR  - N01HC85086/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090115
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
SB  - IM
MH  - Age Distribution
MH  - Aged
MH  - Aging/*physiology
MH  - Atrial Premature Complexes/epidemiology/physiopathology
MH  - Autonomic Nervous System/*physiology
MH  - Cardiovascular Diseases/*epidemiology/*physiopathology
MH  - Cross-Sectional Studies
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Hypertension/epidemiology/physiopathology
MH  - Male
MH  - Nonlinear Dynamics
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Ventricular Premature Complexes/epidemiology/physiopathology
PMC - PMC2724889
EDAT- 2009/01/17 09:00
MHDA- 2009/04/30 09:00
PMCR- 2010/03/01
CRDT- 2009/01/17 09:00
PHST- 2009/01/17 09:00 [entrez]
PHST- 2009/01/17 09:00 [pubmed]
PHST- 2009/04/30 09:00 [medline]
PHST- 2010/03/01 00:00 [pmc-release]
AID - afn292 [pii]
AID - 10.1093/ageing/afn292 [doi]
PST - ppublish
SO  - Age Ageing. 2009 Mar;38(2):212-8. doi: 10.1093/ageing/afn292. Epub 2009 Jan 15.