PMID- 19150139
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20201209
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 49
IP  - 3
DP  - 2009 Nov-Dec
TI  - Efficacy of oxycodone/acetaminophen and codeine/acetaminophen vs. conventional 
      therapy in elderly women with persistent, moderate to severe 
      osteoarthritis-related pain.
PG  - 378-82
LID - 10.1016/j.archger.2008.12.003 [doi]
AB  - We aimed to evaluate the efficacy and safety of oxycodone/acetaminophen (O/A) and 
      codeine/acetaminophen (C/A) vs. conventional therapy (CT) without opioids in 
      older women suffering from osteoarthritis (OA)-related pain, sub-optimally 
      responsive to prior conventional treatments. We performed a 6 week, randomized, 
      single blind, controlled study in three nursing homes. We enrolled 154 women with 
      painful OA. They were assigned to treatment with O/A (n=52) and C/A (n=52) vs. CT 
      (n=50). We evaluated at baseline and at week 6: average pain in the last week 
      (mean pain, MeP), pain at rest (RP), pain in movement (MP) (numeric rating scale, 
      NRS); depressive symptoms (Beck Depression Inventory-II, BDI-II); functional 
      status (activities of daily living, ADL) and cognitive status (mini mental state 
      evaluation, MMSE). We considered the adverse events (AEs) in the study period. At 
      week 6, MeP, RP and MP were significantly reduced in all three groups (p<0.001); 
      compared to CT, O/A and C/A were associated with greater reductions in MeP 
      (p<0.001 and p=0.004, respectively), in RP (p=0.028 and p=0.032, respectively) in 
      MP (p<0.001 and p=0.002, respectively) and with significant improvement in BDI-II 
      score (p=0.05 and p=0.04, respectively) and ADL value (p=0.04 and p=0.05, 
      respectively). AE rates did not differ between groups.
FAU - Corsinovi, Laura
AU  - Corsinovi L
AD  - Section of Geriatrics, Department of Medical and Surgical Disciplines, University 
      of Turin, Ospedale San Giovanni Battista-Molinette, Corso Bramante 88, I-10126 
      Torino, Italy. laura.corsinovi@libero.it
FAU - Martinelli, Elisa
AU  - Martinelli E
FAU - Fonte, Gianfranco
AU  - Fonte G
FAU - Astengo, Marco
AU  - Astengo M
FAU - Sona, Alessandro
AU  - Sona A
FAU - Gatti, Antonia
AU  - Gatti A
FAU - Massaia, Massimiliano
AU  - Massaia M
FAU - Bo, Mario
AU  - Bo M
FAU - Zanocchi, Mauro
AU  - Zanocchi M
FAU - Michelis, Giuliana
AU  - Michelis G
FAU - Isaia, Gianluca
AU  - Isaia G
FAU - Molaschi, Mario
AU  - Molaschi M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20090116
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Drug Combinations)
RN  - 0 (acetaminophen, codeine drug combination)
RN  - 0 (oxycodone-acetaminophen)
RN  - 362O9ITL9D (Acetaminophen)
RN  - CD35PMG570 (Oxycodone)
RN  - UX6OWY2V7J (Codeine)
SB  - IM
MH  - Acetaminophen/*therapeutic use
MH  - Aged
MH  - Analgesics, Non-Narcotic/*therapeutic use
MH  - Analgesics, Opioid/*therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Codeine/*therapeutic use
MH  - Cyclooxygenase 2 Inhibitors/*therapeutic use
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Osteoarthritis/*drug therapy
MH  - Oxycodone/*therapeutic use
MH  - Pain/*drug therapy
MH  - Single-Blind Method
EDAT- 2009/01/20 09:00
MHDA- 2009/11/18 06:00
CRDT- 2009/01/20 09:00
PHST- 2008/06/16 00:00 [received]
PHST- 2008/12/02 00:00 [revised]
PHST- 2008/12/04 00:00 [accepted]
PHST- 2009/01/20 09:00 [entrez]
PHST- 2009/01/20 09:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
AID - S0167-4943(08)00244-6 [pii]
AID - 10.1016/j.archger.2008.12.003 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2009 Nov-Dec;49(3):378-82. doi: 
      10.1016/j.archger.2008.12.003. Epub 2009 Jan 16.