PMID- 19150995
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20131121
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 15
IP  - 1
DP  - 2009 Feb
TI  - Anticoagulation therapy with heparin and warfarin in total knee arthroplasty for 
      osteoarthritis knee.
PG  - 109-12
LID - 10.1177/1076029607304724 [doi]
AB  - The authors evaluated the prophylactic protocols with unfractionated heparin 
      (UFH) and warfarin in Japanese patients who underwent total knee arthroplasty 
      (TKA) for osteoarthritis knee in regard to bleeding complications. Fifty-six 
      patients who underwent TKA for osteoarthritis knee with the use of 
      methylmethacrylate were included. Subcutaneous UFH and warfarin were administered 
      for thromboprophylaxis to the first group of 26 patients. The second group of 30 
      patients did not receive any pharmacological thromboprophylaxis and were used as 
      controls. No significant differences were found between the 2 groups for 
      operative and postoperative blood loss. There were no cases with major bleeding 
      as a complication, but for 2 cases, the international normalized ratio high value 
      exceeded the remedy limits, and temporary dosage discontinuance was required. 
      There were no clinically important bleeding events in the 2 groups. No 
      heparin-induced thrombocytopenia or warfarin-induced skin necrosis occurred. The 
      authors conclude that the protocol with UFH and warfarin is safe for 
      thromboprophylaxis against deep venous thrombosis and pulmonary embolism after 
      TKA in Japanese patients, but its efficacy can only be resolved with further 
      studies.
FAU - Kimura, Kazumasa
AU  - Kimura K
AD  - Department of Orthopaedic Surgery, Kyohritsu General Hospital, Nagoya, Japan. 
      kazwk2003@yahoo.co.jp
FAU - Ohtani, Shigeki
AU  - Ohtani S
FAU - Okamura, Hiroshi
AU  - Okamura H
FAU - Ishii, Nobukazu
AU  - Ishii N
FAU - Kishimoto, Chieko
AU  - Kishimoto C
FAU - Konishi, Kunihiko
AU  - Konishi K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Arthroplasty, Replacement, Knee/adverse effects
MH  - Blood Loss, Surgical/statistics & numerical data
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/surgery
MH  - Postoperative Complications/prevention & control
MH  - Prospective Studies
MH  - Pulmonary Embolism/prevention & control
MH  - Venous Thrombosis/prevention & control
MH  - Warfarin/*therapeutic use
EDAT- 2009/01/20 09:00
MHDA- 2009/03/20 09:00
CRDT- 2009/01/20 09:00
PHST- 2009/01/20 09:00 [entrez]
PHST- 2009/01/20 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
AID - 15/1/109 [pii]
AID - 10.1177/1076029607304724 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2009 Feb;15(1):109-12. doi: 10.1177/1076029607304724.