PMID- 19151342
OWN - NLM
STAT- MEDLINE
DCOM- 20090331
LR  - 20200314
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 88
IP  - 2
DP  - 2009 Feb
TI  - Effects of pig antibacterial peptides on growth performance and intestine mucosal 
      immune of broiler chickens.
PG  - 291-7
LID - 10.3382/ps.2008-00330 [doi]
AB  - Currently, substitutions for antibiotic growth promoters in animals are 
      attracting interest. This study investigated the effects of pig antibacterial 
      peptides (PABP) on growth performance and small intestine mucosal immune 
      responses in broilers. Three hundred 1-d-old Arbor Acre male broiler chickens 
      were randomly allocated to 5 groups with 60 birds per group. The groups were 
      control group; PABP administered in drinking water at 20 and 30 mg/L of water; or 
      PABP supplemented in feed at 150 and 200 mg/kg of diet. The birds were fed a 
      corn-soybean based diet for 6 wk. Chickens were weighed weekly and killed after 
      42 d of feeding, and growth performance was measured. Samples of the duodenum and 
      jejunum were collected. The villus height, mucosa thickness, alkaline phosphatase 
      activity, and numbers of secreting IgA and goblet cells were evaluated. The 
      PABP-treated groups had greater BW and average daily gain, greater height of 
      villus and thickness of gut mucosa, greater activity of alkaline phosphatase, 
      higher ratio of secreting IgA, and a greater number of goblet cells compared with 
      the control group (P<0.05). In conclusion, PABP can improve the growth 
      performance, increase the intestinal ability to absorb nutrients, and improve the 
      mucosal immunity of the intestine.
FAU - Bao, H
AU  - Bao H
AD  - College of Veterinary Medicine, China Agricultural University, Beijing, 100193, 
      PR China.
FAU - She, R
AU  - She R
FAU - Liu, T
AU  - Liu T
FAU - Zhang, Y
AU  - Zhang Y
FAU - Peng, K S
AU  - Peng KS
FAU - Luo, D
AU  - Luo D
FAU - Yue, Z
AU  - Yue Z
FAU - Ding, Y
AU  - Ding Y
FAU - Hu, Y
AU  - Hu Y
FAU - Liu, W
AU  - Liu W
FAU - Zhai, L
AU  - Zhai L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Immunoglobulin A, Secretory)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Alkaline Phosphatase/metabolism
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - *Antimicrobial Cationic Peptides/pharmacology
MH  - Cell Count
MH  - Chickens/*growth & development/*immunology
MH  - Goblet Cells/cytology/drug effects
MH  - Immunoglobulin A, Secretory/metabolism
MH  - Intestinal Mucosa/*drug effects/enzymology/*immunology
MH  - Intestine, Small/cytology/drug effects/enzymology/metabolism
MH  - Male
MH  - Random Allocation
MH  - Swine
EDAT- 2009/01/20 09:00
MHDA- 2009/04/01 09:00
CRDT- 2009/01/20 09:00
PHST- 2009/01/20 09:00 [entrez]
PHST- 2009/01/20 09:00 [pubmed]
PHST- 2009/04/01 09:00 [medline]
AID - S0032-5791(19)39967-5 [pii]
AID - 10.3382/ps.2008-00330 [doi]
PST - ppublish
SO  - Poult Sci. 2009 Feb;88(2):291-7. doi: 10.3382/ps.2008-00330.