PMID- 1915167
OWN - NLM
STAT- MEDLINE
DCOM- 19911106
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 32
IP  - 5
DP  - 1991 Sep-Oct
TI  - Discriminatory effect of cyclic alternating pattern in focal lesional and benign 
      rolandic interictal spikes during sleep.
PG  - 616-28
AB  - Twenty epileptic patients (10 male and 10 female) were polygraphically recorded 
      during nocturnal sleep. Ten subjects, with a wide age range, were affected by 
      focal lesional epilepsy, and 10 were children affected by benign epilepsy with 
      rolandic spikes (BERS). In five cases a bihemispheric expression of the focal 
      lesional bursts emerged occasionally during the night recordings. The behavior of 
      interictal electroencephalographic (EEG) paroxysms were analyzed with respect to 
      the two arousal states of non-rapid-eye-movement (REM) sleep: (a) the cyclic 
      alternating pattern (CAP), expressed by biphasic EEG periodic activities and 
      related to long-lasting fluctuations between greater (phase A) and lesser (phase 
      B) arousal levels; and (b) the non-CAP (NCAP), manifested by EEG stationarities 
      that reflect a sustained relative stability of arousal. The CAP/NCAP modality 
      affected the spiking activity and distribution of the focal lesional EEG 
      paroxysms, which appeared enhanced during CAP and which were mostly collected in 
      phase A. The even more powerful influence of CAP and especially phase A on the 
      secondary bisynchronous bursts suggests a crucial integration among 
      thalamocortical circuits, arousal modulation, and epileptic generalization 
      mechanisms. Conversely, in the BERS recordings no significant differences emerged 
      throughout CAP and NCAP. The intense activity of the rolandic foci induced by 
      sleep as such could be explained on the basis of the greater dependence of these 
      functional cortical EEG abnormalities on the degree of synchronization during 
      sleep.
FAU - Terzano, M G
AU  - Terzano MG
AD  - Department of Neurology, University of Parma, Italy.
FAU - Parrino, L
AU  - Parrino L
FAU - Spaggiari, M C
AU  - Spaggiari MC
FAU - Barusi, R
AU  - Barusi R
FAU - Simeoni, S
AU  - Simeoni S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arousal/*physiology
MH  - Cerebral Cortex/physiopathology
MH  - Child
MH  - Circadian Rhythm/physiology
MH  - Cortical Synchronization
MH  - Diagnosis, Differential
MH  - *Electroencephalography
MH  - Epilepsies, Partial/diagnosis/physiopathology
MH  - Epilepsy/diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neural Pathways/physiopathology
MH  - Sleep/*physiology
MH  - Sleep, REM/physiology
MH  - Thalamus/physiopathology
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
AID - 10.1111/j.1528-1157.1991.tb04700.x [doi]
PST - ppublish
SO  - Epilepsia. 1991 Sep-Oct;32(5):616-28. doi: 10.1111/j.1528-1157.1991.tb04700.x.