PMID- 19151747
OWN - NLM
STAT- MEDLINE
DCOM- 20090403
LR  - 20220317
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 9
IP  - 2
DP  - 2009 Feb
TI  - GATA3 and the T-cell lineage: essential functions before and after 
      T-helper-2-cell differentiation.
PG  - 125-35
LID - 10.1038/nri2476 [doi]
AB  - Many advances in our understanding of the molecules that regulate the 
      development, differentiation and function of T cells have been made over the past 
      few years. One important regulator of T-cell differentiation is the transcription 
      factor GATA-binding protein 3 (GATA3). Although the main function of GATA3 is to 
      act as a master transcription factor for the differentiation of T helper 2 
      (T(H)2) cells, new research has helped to uncover crucial functions of GATA3 in T 
      cells that go beyond T(H)2-cell differentiation and that are important at earlier 
      stages of haematopoietic and lymphoid-cell development. This Review focuses on 
      the functions of GATA3 from early thymocyte development to effector T-cell 
      differentiation. In addition, we discuss the interactions between GATA3 and other 
      transcription factors and signalling pathways, and highlight the functional 
      significance of the GATA3 protein structure.
FAU - Ho, I-Cheng
AU  - Ho IC
AD  - Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, 
      Harvard Medical School, Boston, Massachusetts 02115, USA. iho@partners.org
FAU - Tai, Tzong-Shyuan
AU  - Tai TS
FAU - Pai, Sung-Yun
AU  - Pai SY
LA  - eng
GR  - R01 AI054451/AI/NIAID NIH HHS/United States
GR  - R01 AI054451-05/AI/NIAID NIH HHS/United States
GR  - K01 AI050601/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (GATA3 Transcription Factor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Lineage/*immunology
MH  - GATA3 Transcription Factor/chemistry/*metabolism
MH  - Humans
MH  - Lymphopoiesis
MH  - Molecular Sequence Data
MH  - Signal Transduction
MH  - Th2 Cells/*immunology
MH  - Thymus Gland/immunology
PMC - PMC2998182
MID - NIHMS253792
EDAT- 2009/01/20 09:00
MHDA- 2009/04/04 09:00
PMCR- 2010/12/07
CRDT- 2009/01/20 09:00
PHST- 2009/01/20 09:00 [entrez]
PHST- 2009/01/20 09:00 [pubmed]
PHST- 2009/04/04 09:00 [medline]
PHST- 2010/12/07 00:00 [pmc-release]
AID - nri2476 [pii]
AID - 10.1038/nri2476 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2009 Feb;9(2):125-35. doi: 10.1038/nri2476.