PMID- 19152241
OWN - NLM
STAT- MEDLINE
DCOM- 20090609
LR  - 20220330
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 56
IP  - 1
DP  - 2009
TI  - Association of interleukin-18 gene promoter polymorphisms with breast cancer.
PG  - 22-5
AB  - Interleukin-18 [IL-18] gene promoter polymorphism is reported to be a genetic 
      risk factor for several types of cancer. The aims of this investigation were to 
      evaluate and compare the frequencies of IL-18 gene promoter polymorphisms at 
      positions -137 [G/C] and -607 [C/A] in breast cancer patients and healthy 
      controls as well as to study the contribution of these data with 
      clinicopathological parameters at diagnosis. The studied populations comprised 
      250 cases with breast carcinoma and 206 healthy subjects. IL-18 gene promoter 
      polymorphisms at positions -137 and -607 were amplified in patient and control 
      groups using allele specific polymerase chain reaction [AS-PCR]. The frequencies 
      of GG, GC and CC genotypes of -137 SNP were 141 [56.4%], 96 [38.4%] and 13 [5.2%] 
      in patients vs. 110 [53.4%], 72 [34.9%] and 24 [11.7%] in controls, respectively. 
      A significant decrease of the CC genotype was observed in patients [p = 0.04]. 
      The frequency of the CC genotype at position -137 was also significantly higher 
      in patients with metastasis than non-metastatic patients [21.4% vs. 4.3%] [p = 
      0.02]. There was no significant association between genotype frequencies at 
      position -607 with breast cancer or its clinicopathological parameters at 
      diagnosis. Moreover, allelic frequencies at these positions did not contribute to 
      breast cancer incidence. The distribution of IL-18 gene haplotypes and genotype 
      combinations were not significantly different between patients and normal control 
      individuals. This is the first report investigating the contribution of IL-18 
      gene promoter polymorphisms to breast cancer. These results suggest contrast 
      effects of IL-18 gene in cancer induction and progression. Key words: Breast 
      cancer, IL-18, polymorphism.
FAU - Khalili-Azad, T
AU  - Khalili-Azad T
AD  - Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Razmkhah, M
AU  - Razmkhah M
FAU - Ghiam, A F
AU  - Ghiam AF
FAU - Doroudchi, M
AU  - Doroudchi M
FAU - Talei, A R
AU  - Talei AR
FAU - Mojtahedi, Z
AU  - Mojtahedi Z
FAU - Ghaderi, A
AU  - Ghaderi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*genetics/pathology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2009/01/20 09:00
MHDA- 2009/06/10 09:00
CRDT- 2009/01/20 09:00
PHST- 2009/01/20 09:00 [entrez]
PHST- 2009/01/20 09:00 [pubmed]
PHST- 2009/06/10 09:00 [medline]
AID - 10.4149/neo_2009_01_22 [doi]
PST - ppublish
SO  - Neoplasma. 2009;56(1):22-5. doi: 10.4149/neo_2009_01_22.