PMID- 19153174
OWN - NLM
STAT- MEDLINE
DCOM- 20090710
LR  - 20220321
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 15
IP  - 4
DP  - 2009 Apr
TI  - Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis.
PG  - 431-6
LID - 10.1177/1352458508100037 [doi]
AB  - BACKGROUND: Both human leukocyte antigen (HLA)-DRB1*15 and Epstein-Barr virus 
      infection presenting as infectious mononucleosis (IM) are recognized as risk 
      factors for multiple sclerosis (MS). However, their combined effect and possible 
      interaction on MS risk is not known. OBJECTIVE: To assess the association between 
      HLA-DRB1*15 and risk of MS in persons with and without IM. METHODS: We compared 
      the prevalence of DRB1*15 in MS patients with (n = 76) and without (n = 1,836) IM 
      with the corresponding distributions in blood donors with (n = 62) and without (n 
      = 484) IM histories. This allowed us to estimate the relative risk of MS 
      associated with DRB1*15 in the presence and absence, respectively, of previous 
      IM. We then estimated the interaction between DRB1*15 and IM as the ratio of the 
      two individual odds ratios. RESULTS: In IM-naive individuals, DRB1*15 carried a 
      2.4-fold (95% confidence interval [CI], 2.0-3.0) increased MS risk. In contrast, 
      among persons with IM history, DRB1*15 was associated with a 7.0-fold (95% CI, 
      3.3-15.4) increased MS risk. Thus, the MS risk conferred by HLA-DRB1*15 was 2.9 
      (95% CI, 1.3-6.5)-fold stronger in the presence than in the absence of IM. 
      Combined with previous results, this result indicates that DRB1*15-positive 
      persons with a history of IM may be at a 10.0-fold (95% CI, 6.0-17.9) increased 
      risk of MS compared with persons who are DRB1*15 and IM-naive. CONCLUSION: 
      DRB1*15 and IM may act in synergy causing MS.
FAU - Nielsen, T R
AU  - Nielsen TR
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. 
      trn@ssi.dk
FAU - Rostgaard, K
AU  - Rostgaard K
FAU - Askling, J
AU  - Askling J
FAU - Steffensen, R
AU  - Steffensen R
FAU - Oturai, A
AU  - Oturai A
FAU - Jersild, C
AU  - Jersild C
FAU - Koch-Henriksen, N
AU  - Koch-Henriksen N
FAU - Sorensen, P S
AU  - Sorensen PS
FAU - Hjalgrim, H
AU  - Hjalgrim H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090119
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15 antigen)
SB  - IM
CIN - Mult Scler. 2010 Jan;16(1):127-8. PMID: 20051521
MH  - Genetic Predisposition to Disease/epidemiology
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infectious Mononucleosis/*epidemiology/*genetics
MH  - *Multiple Sclerosis/epidemiology/genetics/virology
MH  - Prevalence
MH  - Risk Factors
EDAT- 2009/01/21 09:00
MHDA- 2009/07/11 09:00
CRDT- 2009/01/21 09:00
PHST- 2009/01/21 09:00 [entrez]
PHST- 2009/01/21 09:00 [pubmed]
PHST- 2009/07/11 09:00 [medline]
AID - 1352458508100037 [pii]
AID - 10.1177/1352458508100037 [doi]
PST - ppublish
SO  - Mult Scler. 2009 Apr;15(4):431-6. doi: 10.1177/1352458508100037. Epub 2009 Jan 
      19.