PMID- 19153535
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20090227
IS  - 1323-8930 (Print)
IS  - 1323-8930 (Linking)
VI  - 58
IP  - 1
DP  - 2009 Mar
TI  - Age-related changes of transforming growth factor beta1 in Japanese children.
PG  - 97-102
LID - 10.2332/allergolint.O-07-530 [doi]
AB  - BACKGROUND: Transforming growth factor beta1 (TGF beta 1) is an important factor 
      in immunomodulation. The expression of TGF beta 1 has been shown to be influenced 
      by the C-509T polymorphism in the TGF beta 1 gene. We investigated age-related 
      changes of plasma TGF beta 1 levels in a birth-cohort study. In addition, the 
      genotypes of the C-509T polymorphism were investigated in allergic and 
      non-allergic subjects. METHODS: Sixty-four neonates who met the following 
      criteria were enrolled in this cohort study: 1) full-term vaginally delivery; 2) 
      underwent DNA polymorphism analysis; and 3) questionnaire forms were filled out 
      by parents at 0, 6 and 14 months of age. The umbilical cord blood at 0 months and 
      peripheral blood at 6, and 14 months were collected. Plasma TGF beta1 levels were 
      measured at 0, 6 and 14 months of age. Genomic DNA was extracted from their 
      umbilical cord blood. The genotype of the subjects was examined for the presence 
      of C-509T. RESULTS: The plasma TGF beta 1 level at 6 months was the highest of 
      the 3 measurements (at 0, 6, and 14 months of age). The TGF beta 1 levels at 14 
      months in allergic subjects were significantly higher than those in non-allergic 
      subjects (p = 0.03). All subjects with bronchial asthma (n = 3) had the TT 
      genotype of the C-509T polymorphism. CONCLUSIONS: The plasma TGF beta 1 levels 
      change with age. In addition, TGF beta 1 may play a role in the pathogenesis of 
      bronchial asthma.
FAU - Morimoto, Masahiro
AU  - Morimoto M
AD  - Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, 
      Japan.
FAU - Matsui, Eiko
AU  - Matsui E
FAU - Kawamoto, Norio
AU  - Kawamoto N
FAU - Sakurai, Satomi
AU  - Sakurai S
FAU - Kaneko, Hideo
AU  - Kaneko H
FAU - Fukao, Toshiyuki
AU  - Fukao T
FAU - Iwasa, Shinichi
AU  - Iwasa S
FAU - Shiraki, Makoto
AU  - Shiraki M
FAU - Kasahara, Kimiko
AU  - Kasahara K
FAU - Kondo, Naomi
AU  - Kondo N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090125
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Transforming Growth Factor beta1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Transforming Growth Factor beta1/*blood/genetics/physiology
EDAT- 2009/01/21 09:00
MHDA- 2009/07/08 09:00
CRDT- 2009/01/21 09:00
PHST- 2007/12/03 00:00 [received]
PHST- 2008/07/22 00:00 [accepted]
PHST- 2009/01/21 09:00 [entrez]
PHST- 2009/01/21 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
AID - S1323-8930(15)30667-5 [pii]
AID - 10.2332/allergolint.O-07-530 [doi]
PST - ppublish
SO  - Allergol Int. 2009 Mar;58(1):97-102. doi: 10.2332/allergolint.O-07-530. Epub 2009 
      Jan 25.