PMID- 19154253
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20220316
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 20
IP  - 1
DP  - 2009 Feb
TI  - Mechanisms of food allergy.
PG  - 5-11
LID - 10.1111/j.1399-3038.2008.00847.x [doi]
AB  - Allergy type sensitization occurring in the gut results from a break in oral 
      tolerance, mostly occurring in early childhood. In these patients, a minute 
      amount of the large load of potential food allergens not only will result in 
      immunoglobulin E (IgE) type sensitization mostly, but also in food allergies 
      resulting from other mechanisms including eosinophil-driven disease or resulting 
      from T-cell-mediated inflammation. Symptoms elicited by subsequent exposure to 
      foods in these patients will be mostly in relation to the mechanism of the 
      disease. In this educational review series, we described three cases of food 
      allergy, first, a child with typical IgE-mediated food allergy, second, a child 
      with eosinophilic proctocolitis and in the third patient, we will address 
      tolerance acquisition mechanisms. These cases are discussed with regards to their 
      specific immune events.
FAU - Eigenmann, Philippe A
AU  - Eigenmann PA
AD  - Department of Pediatrics, Geneva University Hospitals and University of Geneva, 
      Geneva, Switzerland. philippe.eigenmann@hcuge.ch
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Egg Proteins)
RN  - 0 (Platelet Activating Factor)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Arachis/immunology
MH  - Breast Feeding
MH  - Cytokines/immunology
MH  - Egg Hypersensitivity/diagnosis/*immunology
MH  - Egg Proteins/immunology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Intestinal Mucosa/*immunology
MH  - Male
MH  - Mast Cells/immunology
MH  - Milk/immunology
MH  - Milk Hypersensitivity/diagnosis/*immunology
MH  - Peanut Hypersensitivity/diagnosis/*immunology
MH  - Platelet Activating Factor/immunology
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 2009/01/22 09:00
MHDA- 2009/02/25 09:00
CRDT- 2009/01/22 09:00
PHST- 2009/01/22 09:00 [entrez]
PHST- 2009/01/22 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
AID - PAI847 [pii]
AID - 10.1111/j.1399-3038.2008.00847.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2009 Feb;20(1):5-11. doi: 
      10.1111/j.1399-3038.2008.00847.x.