PMID- 19156544 OWN - NLM STAT- MEDLINE DCOM- 20090330 LR - 20220321 IS - 0893-7648 (Print) IS - 1559-1182 (Electronic) IS - 0893-7648 (Linking) VI - 39 IP - 1 DP - 2009 Feb TI - Activity-dependent dendritic release of BDNF and biological consequences. PG - 37-49 LID - 10.1007/s12035-009-8050-7 [doi] AB - Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival neurotrophins, modulate nearly all key steps of network construction from neuronal migration to experience-dependent refinement of local connections. In this paper, we provide an overview of recent findings showing that BDNF can serve as a target-derived messenger for activity-dependent synaptic plasticity and development at the single cell level. FAU - Kuczewski, Nicola AU - Kuczewski N AD - INMED (Institut de Neurobiologie de la Mediterranee), INSERM (Institut National de la Sante et de la Recherche Medicale Unite 901), Universite de La Mediterranee, Parc scientifique de Luminy, Marseille Cedex 09, France. kuczewski@inmed.univ-mrs.fr FAU - Porcher, Christophe AU - Porcher C FAU - Lessmann, Volkmar AU - Lessmann V FAU - Medina, Igor AU - Medina I FAU - Gaiarsa, Jean-Luc AU - Gaiarsa JL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20090122 PL - United States TA - Mol Neurobiol JT - Molecular neurobiology JID - 8900963 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Action Potentials/physiology MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Cell Communication/physiology MH - Dendrites/*metabolism/ultrastructure MH - Synapses/metabolism PMC - PMC5352827 EDAT- 2009/01/22 09:00 MHDA- 2009/03/31 09:00 CRDT- 2009/01/22 09:00 PHST- 2008/12/01 00:00 [received] PHST- 2009/01/07 00:00 [accepted] PHST- 2009/01/22 09:00 [entrez] PHST- 2009/01/22 09:00 [pubmed] PHST- 2009/03/31 09:00 [medline] AID - 10.1007/s12035-009-8050-7 [doi] PST - ppublish SO - Mol Neurobiol. 2009 Feb;39(1):37-49. doi: 10.1007/s12035-009-8050-7. Epub 2009 Jan 22.