PMID- 19156700
OWN - NLM
STAT- MEDLINE
DCOM- 20100825
LR  - 20161125
IS  - 1099-1166 (Electronic)
IS  - 0885-6230 (Linking)
VI  - 24
IP  - 9
DP  - 2009 Sep
TI  - Expert opinion on the management of behavioural and psychological symptoms of 
      dementia (BPSD) and investigation into prescribing practices in the UK.
PG  - 944-54
LID - 10.1002/gps.2200 [doi]
AB  - BACKGROUND: The management of Behavioural and Psychological Symptoms of Dementia 
      (BPSD) has been the subject of considerable debate over the last few years in 
      view of the poor evidence base for pharmacological agents and concerns about 
      their safety. OBJECTIVES: This study sought to obtain expert opinion on the 
      management of BPSD and to investigate current prescribing practices in the UK. 
      METHOD: A total of 166 expert opinion surveys were emailed to UK consultants in 
      Old Age Psychiatry asking them to rate the appropriateness of psychotropics in 
      different aspects of BPSD. A service evaluation was also carried out in 8 UK 
      centres to investigate prescribing patterns. RESULTS: Overall, 59 consultants 
      returned completed questionnaires, a response rate of 35%. Results revealed that 
      experts rated quetiapine as the most appropriate agent for all BPSD followed by 
      acetylcholinesterase inhibitors for psychotic symptoms, benzodiazepines for 
      agitation or aggression and trazodone for behavioural symptoms such as 
      disinhibition. The service evaluations showed that benzodiazepines were most 
      frequently prescribed for BPSD. CONCLUSIONS: Although quetiapine was judged by 
      experts to be the most appropriate agent for BPSD, it appears that in clinical 
      practice benzodiazepines are most often used to manage these symptoms. Evidence 
      from both studies show wide inconsistencies in prescribing trends.
FAU - Bishara, Delia
AU  - Bishara D
AD  - Pharmacy Department, Maudsley Hospital, London, UK. delia.bishara@slam.nhs.uk
FAU - Taylor, David
AU  - Taylor D
FAU - Howard, Robert J
AU  - Howard RJ
FAU - Abdel-Tawab, Rauja
AU  - Abdel-Tawab R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Geriatr Psychiatry
JT  - International journal of geriatric psychiatry
JID - 8710629
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Cholinesterase Inhibitors)
SB  - IM
MH  - Aged, 80 and over
MH  - Antipsychotic Agents/*therapeutic use
MH  - Cholinesterase Inhibitors/*therapeutic use
MH  - Dementia/*drug therapy/psychology
MH  - Drug Prescriptions
MH  - Evidence-Based Medicine
MH  - *Expert Testimony
MH  - Female
MH  - Guideline Adherence
MH  - Humans
MH  - Male
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2009/01/22 09:00
MHDA- 2010/08/26 06:00
CRDT- 2009/01/22 09:00
PHST- 2009/01/22 09:00 [entrez]
PHST- 2009/01/22 09:00 [pubmed]
PHST- 2010/08/26 06:00 [medline]
AID - 10.1002/gps.2200 [doi]
PST - ppublish
SO  - Int J Geriatr Psychiatry. 2009 Sep;24(9):944-54. doi: 10.1002/gps.2200.