PMID- 19156719
OWN - NLM
STAT- MEDLINE
DCOM- 20090826
LR  - 20090617
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 53
IP  - 6
DP  - 2009 Jun
TI  - Association between functional FABP2 promoter haplotypes and body mass index: 
      analyses of 8072 participants of the KORA cohort study.
PG  - 681-5
LID - 10.1002/mnfr.200800225 [doi]
AB  - Studies in relatively small cohorts provide preliminary evidence that functional 
      fatty acid binding protein 2 (FABP2) promoter haplotypes are associated with type 
      2 diabetes and BMI. Here, we studied the influence of the haplotypes on BMI by 
      using 8072 male and female participants of the Kooperative Gesundheitsforschung 
      in der Region Augsburg (KORA) cohort. By linear regression analysis, we found in 
      males a reduction of -0.39 BMI units (95% CI: -0.73, -0.05, p = 0.024) in 
      homozygous FABP2 promoter haplotype B carriers. Carriers of haplotype B showed a 
      significant decrease in BMI of -0.19 BMI units (95% CI: -0.35, -0.02, p = 0.027). 
      In accordance, a significant reduction in BMI of the minor haplotype carriers in 
      the BMI point categories of 25-30 (BMI units: -0.10, 95% CI: -0.18, -0.01, p = 
      0.03) and < 30 (BMI units: -0.37, 95% CI: -0.67, -0.07, p = 0.02) were found. In 
      summary, the minor FABP2 promoter haplotype B contributes to a reduced BMI in 
      men. This provides evidence that functional FABP2 contributes to multifactorialy 
      regulated body weight.
FAU - Bohme, Mike
AU  - Bohme M
AD  - Institute of Human Nutrition and Food Science, Molecular Nutrition, 
      Christian-Albrecht-University, Kiel, Germany.
FAU - Grallert, Harald
AU  - Grallert H
FAU - Klapper, Maja
AU  - Klapper M
FAU - Gieger, Christian
AU  - Gieger C
FAU - Fischer, Alexandra
AU  - Fischer A
FAU - Heid, Iris
AU  - Heid I
FAU - Wichmann, H-Erich
AU  - Wichmann HE
FAU - Doring, Frank
AU  - Doring F
FAU - Illig, Thomas
AU  - Illig T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (FABP2 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Body Mass Index
MH  - Cohort Studies
MH  - Fatty Acid-Binding Proteins/*genetics
MH  - Female
MH  - *Haplotypes
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Promoter Regions, Genetic
EDAT- 2009/01/22 09:00
MHDA- 2009/08/27 09:00
CRDT- 2009/01/22 09:00
PHST- 2009/01/22 09:00 [entrez]
PHST- 2009/01/22 09:00 [pubmed]
PHST- 2009/08/27 09:00 [medline]
AID - 10.1002/mnfr.200800225 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2009 Jun;53(6):681-5. doi: 10.1002/mnfr.200800225.