PMID- 19157498
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20190420
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 75
IP  - 5
DP  - 2009 May
TI  - Prevalence of diabetes and body burdens of polychlorinated biphenyls, 
      polybrominated diphenyl ethers, and p,p'-diphenyldichloroethene in Great Lakes 
      sport fish consumers.
PG  - 674-679
LID - S0045-6535(08)01560-9 [pii]
LID - 10.1016/j.chemosphere.2008.12.035 [doi]
AB  - Recent studies have demonstrated ubiquitous exposure to persistent organic 
      pollutants (POPs) such as p,p'-diphenyldichloroethene (DDE), polychlorinated 
      biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). Although several 
      studies have noted associations of dioxins, PCBs and DDE with diabetes, the 
      results have not always been consistent, with few examining effects of PBDEs or 
      simultaneous exposures. The purpose of this study was to determine whether POP 
      body burdens are related to diabetes in a cross section of Great Lake sport fish 
      consumers. The cohort, which was established in the early 1990s, was recontacted 
      in 2004-2005. Serum was collected and tested for DDE, PCBs, PBDEs, hemoglobin A1c 
      and lipids, and diabetes diagnosis, demographics and fish consumption were 
      assessed by self report. Associations of diabetes with exposures were examined in 
      cross sectional data from 2004 to 2005. DDE exposure and dioxin-like mono-ortho 
      PCBs were associated with diabetes, but the association of dioxin-like mono-ortho 
      PCBs with diabetes did not remain significant after control for DDE exposure. 
      Neither the sum of PCBs or years of sport fish consumption were associated with 
      prevalent diabetes. There was a non-significant association of PBDEs with 
      diabetes only in those with hypothyroid disease. The current study confirms 
      previous cross sectional associations of DDE exposure with diabetes. Future 
      studies should address biologic pathways by which selective POPs affect glucose 
      homeostasis.
FAU - Turyk, Mary
AU  - Turyk M
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, 1603 W. Taylor Street, Room 897, Chicago, IL 60612, 
      United States. Electronic address: mturyk1@uic.edu.
FAU - Anderson, Henry A
AU  - Anderson HA
AD  - Wisconsin Division of Public Health, Bureau of Environmental Health, 1 W. Wilson 
      Street, Madison, WI 53703, United States.
FAU - Knobeloch, Lynda
AU  - Knobeloch L
AD  - Wisconsin Division of Public Health, Bureau of Environmental Health, 1 W. Wilson 
      Street, Madison, WI 53703, United States.
FAU - Imm, Pamela
AU  - Imm P
AD  - Wisconsin Division of Public Health, Bureau of Environmental Health, 1 W. Wilson 
      Street, Madison, WI 53703, United States.
FAU - Persky, Victoria W
AU  - Persky VW
AD  - Division of Epidemiology and Biostatistics, School of Public Health, University 
      of Illinois at Chicago, 1603 W. Taylor Street, Room 897, Chicago, IL 60612, 
      United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090120
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Body Burden
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Demography
MH  - Diabetes Mellitus/*epidemiology
MH  - Dichlorodiphenyl Dichloroethylene/*blood
MH  - Environmental Exposure
MH  - Fishes
MH  - Food Contamination/*analysis
MH  - Great Lakes Region
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Prevalence
EDAT- 2009/01/23 09:00
MHDA- 2009/06/12 09:00
CRDT- 2009/01/23 09:00
PHST- 2008/10/13 00:00 [received]
PHST- 2008/12/11 00:00 [revised]
PHST- 2008/12/14 00:00 [accepted]
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
AID - S0045-6535(08)01560-9 [pii]
AID - 10.1016/j.chemosphere.2008.12.035 [doi]
PST - ppublish
SO  - Chemosphere. 2009 May;75(5):674-679. doi: 10.1016/j.chemosphere.2008.12.035. Epub 
      2009 Jan 20.