PMID- 19158410
OWN - NLM
STAT- MEDLINE
DCOM- 20090605
LR  - 20211020
IS  - 0363-6119 (Print)
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 296
IP  - 4
DP  - 2009 Apr
TI  - Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity 
      gene network in vivo and in vitro.
PG  - R1180-9
LID - 10.1152/ajpregu.90813.2008 [doi]
AB  - Hypothalamic neuropeptides, neurotrophins, and systemic hormones modulate food 
      intake and body composition. Although advances toward elucidating these 
      interactions have been made, many aspects of the underlying mechanisms remain 
      vague. Hypothalami from fat and lean chicken lines were assessed for differential 
      expression of anabolic/orexigenic and catabolic/anorexigenic genes. Effects of 
      triiodothyronine (T(3)), corticosterone (Cort), and brain-derived neurotrophic 
      factor (BDNF) on expression of anabolic/orexigenic and catabolic/anorexigenic 
      genes were tested in cultures of hypothalamic neurons. From this, we found that 
      BDNF increased and T(3) decreased gene expression for BDNF, leptin receptor 
      (LEPR), pro-opiomelanocortin (POMC), thyrotropin releasing hormone (TRH), and 
      agouti-related protein (AGRP). Thyroid hormone levels were manipulated during 
      development to show that T(3) inhibited BDNF, TRH, and BDNF receptor gene 
      expression. Delivery of T(3), Cort, T(3) plus Cort, or vehicle in vivo 
      continuously for 72 h indicated that Cort and T(3) have overlapping roles in 
      regulating TRH, LEPR, and POMC gene expression and that Cort and T(3) regulate 
      BDNF, neuropeptide Y, and AGRP in opposite directions. Collectively, these 
      findings suggest that interactions between the neuropeptide BDNF and the hormones 
      T(3) and/or Cort may constitute a homeostatic mechanism that links hypothalamic 
      energy regulation controlling body composition.
FAU - Byerly, Mardi S
AU  - Byerly MS
AD  - Department of Animal and Avian Sciences, University of Maryland, College Park, MD 
      20712, USA.
FAU - Simon, Jean
AU  - Simon J
FAU - Lebihan-Duval, Elisabeth
AU  - Lebihan-Duval E
FAU - Duclos, Michel J
AU  - Duclos MJ
FAU - Cogburn, Larry A
AU  - Cogburn LA
FAU - Porter, Tom E
AU  - Porter TE
LA  - eng
GR  - MH-20048/MH/NIMH NIH HHS/United States
GR  - F31 DK-743802/DK/NIDDK NIH HHS/United States
GR  - F31 DK074380-02/DK/NIDDK NIH HHS/United States
GR  - F31 DK074380/DK/NIDDK NIH HHS/United States
GR  - F31 DK074380-01A1/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090121
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Body Composition/genetics
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cells, Cultured
MH  - Chick Embryo
MH  - Chickens
MH  - Corticosterone/*metabolism
MH  - Energy Metabolism/genetics
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - *Gene Regulatory Networks
MH  - Hypothalamus/embryology/*metabolism
MH  - Neurons/*metabolism
MH  - Obesity/*genetics/metabolism/physiopathology/veterinary
MH  - RNA, Messenger/metabolism
MH  - Response Elements
MH  - Triiodothyronine/*metabolism
PMC - PMC2698606
EDAT- 2009/01/23 09:00
MHDA- 2009/06/06 09:00
PMCR- 2010/04/01
CRDT- 2009/01/23 09:00
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 90813.2008 [pii]
AID - R-90813-2008 [pii]
AID - 10.1152/ajpregu.90813.2008 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1180-9. doi: 
      10.1152/ajpregu.90813.2008. Epub 2009 Jan 21.