PMID- 19159430
OWN - NLM
STAT- MEDLINE
DCOM- 20090413
LR  - 20211020
IS  - 1574-695X (Electronic)
IS  - 0928-8244 (Print)
IS  - 0928-8244 (Linking)
VI  - 55
IP  - 2
DP  - 2009 Mar
TI  - Identification of dendritic cell subsets responding to genital infection by 
      Chlamydia muridarum.
PG  - 226-36
LID - 10.1111/j.1574-695X.2008.00523.x [doi]
AB  - Dendritic cells (DCs) are central for the induction of T-cell responses needed 
      for chlamydial eradication. Here, we report the activation of two DC subsets: a 
      classical CD11b+ (cDC) and plasmacytoid (pDC) during genital infection with 
      Chlamydia muridarum. Genital infection induced an influx of cDC and pDC into the 
      genital tract and its draining lymph node (iliac lymph nodes, ILN) as well as 
      colocalization with T cells in the ILN. Genital infection with C. muridarum also 
      stimulated high levels of costimulatory molecules on cDC central for the 
      activation of naive T cells in vivo. In contrast, pDC expressed low levels of 
      most costimulatory molecules in vivo and did not secrete cytokines associated 
      with the production of T helper (Th)1 cells in vitro. However, pDC upregulated 
      inducible costimulatory ligand expression and produced IL-6 and IL-10 in response 
      to chlamydial exposure in vitro. Our findings show that these two DC subsets 
      likely have different functions in vivo. cDCs are prepared for induction of 
      antichlamydial T-cell responses, whereas pDCs have characteristics associated 
      with the differentiation of non-Th1 cell subsets.
FAU - Moniz, Raymond J
AU  - Moniz RJ
AD  - Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 
      University of California Los Angeles, 90095, USA.
FAU - Chan, Ann M
AU  - Chan AM
FAU - Kelly, Kathleen A
AU  - Kelly KA
LA  - eng
GR  - CA-16042/CA/NCI NIH HHS/United States
GR  - R01 AI026328-15/AI/NIAID NIH HHS/United States
GR  - AI-28697/AI/NIAID NIH HHS/United States
GR  - T32 AI107126-28/AI/NIAID NIH HHS/United States
GR  - T32 AI052031/AI/NIAID NIH HHS/United States
GR  - P30 AI028697/AI/NIAID NIH HHS/United States
GR  - P30 CA016042/CA/NCI NIH HHS/United States
GR  - R01 AI026328/AI/NIAID NIH HHS/United States
GR  - T32 AI52031/AI/NIAID NIH HHS/United States
GR  - R01 IA-026328/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090112
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Chlamydia Infections/*immunology/*microbiology
MH  - Chlamydia muridarum/*immunology
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/classification/*immunology/*microbiology
MH  - Female
MH  - Genital Diseases, Female/*immunology/*microbiology
MH  - Mice
MH  - Mice, Inbred BALB C
PMC - PMC3304542
MID - NIHMS92824
EDAT- 2009/01/23 09:00
MHDA- 2009/04/14 09:00
PMCR- 2012/03/15
CRDT- 2009/01/23 09:00
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/04/14 09:00 [medline]
PHST- 2012/03/15 00:00 [pmc-release]
AID - FIM523 [pii]
AID - 10.1111/j.1574-695X.2008.00523.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 2009 Mar;55(2):226-36. doi: 
      10.1111/j.1574-695X.2008.00523.x. Epub 2009 Jan 12.