PMID- 19159526
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20160818
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 37
IP  - 12
DP  - 2008 Dec
TI  - [Primary ocular adnexal lymphoproliferative lesions: clinicopathologic features 
      and genetic alterations].
PG  - 809-14
AB  - OBJECTIVE: To investigate clinicopathological and genetic characteristics of 
      primary ocular adnexal lymphoproliferative lesions. METHODS: Clinical, 
      morphological and immunohistochemical features of 37 archival cases of primary 
      ocular adnexal lymphoproliferative lesions were studied including 5 cases of 
      reactive lymphoid hyperplasia and 32 lymphomas retrospectively. Classification of 
      the lymphomas were made according to the WHO classification of tumors of 
      haematopoietic and lymphoid tissues. All cases were studied by interphase 
      fluorescence in situ hybridization (FISH) using dual color break apart probes of 
      IgH, MALT1, bcl-6, c-Myc, bcl-2, CCND1, bcl-10, and FOXP1 for detection of 
      chromosomal aberrations involving IgH, MALT1, bcl-6, c-Myc, bcl-2, cyclinD1, 
      bcl-10 and FOXP1 genes, respectively. FISH with IgH / bcl-2 dual color dual 
      fusion probe was used for detection of t(14;18)(q32;q21)/IgH-bcl-2. CEP18 
      spectrum orange probe was used for detection of aneuploidy of the chromosome 18. 
      RESULTS: Among 32 cases of lymphomas, 28 cases (87.5%) were extranodal marginal 
      zone B-cell lymphomas of mucosa associated lymphoid tissue (MALT lymphoma), 2 
      cases were follicular lymphoma (FL) and 2 cases diffuse large B cell lymphoma 
      (DLBCL). Among the 28 cases of MALT lymphoma, chromosomal aberrations were found 
      in 60.7% (17/28) by interphase FISH analysis. One case showed positive IgH 
      break-apart signal with unknown partner. 16 cases showed three copies of 
      different genes, of which, three copies of MALT1, bcl-6, and c-Myc were 
      identified in 7 cases (25%), 12 cases (43%), and 2 cases (8%) of MALT lymphomas, 
      respectively. In addition, 5 cases showed two genes including three copies of 
      bcl-6 and MALT1 in 4 cases, and three copies of bcl-6 together with c-Myc in one 
      case. Furthermore, all cases with three copies of MALT1 had trisomy 18. 
      t(14;18)(q32;q21) was detected in both follicular lymphomas. Of the 2 DLBCL 
      cases, one showed three copies of bcl-6 together with trisomy 18 and the other 
      one showed three copies of bcl-6 together with IgH and c-Myc rearrangements. 
      Chromosomal aberration was not found in all 5 cases of reactive lymphoid 
      hyperplasia. CONCLUSIONS: The most common entity of primary ocular adnexal 
      lymphomas is MALT lymphoma and FISH is helpful for their differential diagnosis 
      and classification. Trisomy 18 and three copies of bcl-6 are common chromosomal 
      aberrations in primary ocular adnexal MALT lymphomas.
FAU - Dong, Li-Na
AU  - Dong LN
AD  - Department of Pathology, Basic Medical College, Capital Medical University, 
      Beijing 100069, China.
FAU - Liu, Hong-Gang
AU  - Liu HG
FAU - Jin, Ha-Si
AU  - Jin HS
FAU - Ye, Hong-Tao
AU  - Ye HT
FAU - Gao, Zi-Fen
AU  - Gao ZF
FAU - Zhou, Xiao-Ge
AU  - Zhou XG
FAU - Dong, Ge-Hong
AU  - Dong GH
FAU - Zhang, Dan-Dan
AU  - Zhang DD
FAU - Gong, Li-Ping
AU  - Gong LP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Aneuploidy
MH  - B-Lymphocytes/pathology
MH  - Caspases/genetics
MH  - Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - Eye/pathology
MH  - Eye Neoplasms/*genetics/pathology
MH  - Female
MH  - Genes, bcl-2/*genetics
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Lymphoma, B-Cell/*genetics
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/genetics/pathology
MH  - Male
MH  - *Mutation
MH  - Translocation, Genetic
MH  - Trisomy
EDAT- 2009/01/23 09:00
MHDA- 2010/10/30 06:00
CRDT- 2009/01/23 09:00
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2008 Dec;37(12):809-14.