PMID- 19159688
OWN - NLM
STAT- MEDLINE
DCOM- 20090601
LR  - 20220409
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 113
IP  - 3-5
DP  - 2009 Feb
TI  - Testosterone action on erythropoiesis does not require its aromatization to 
      estrogen: Insights from the testosterone and estrogen treatment of two 
      aromatase-deficient men.
PG  - 189-94
LID - 10.1016/j.jsbmb.2008.12.007 [doi]
AB  - Androgens act on erythropoiesis, but the relative role of testosterone (T) and 
      estradiol (E(2)) on erythropoietic parameters in men is a poorly investigated 
      issue. In order to evaluate separately the effects on erythropoiesis of high-dose 
      T administration alone and of physiological dose of E(2) administration alone two 
      adult men with aromatase deficiency were assessed before and during each 
      treatment. Blood cell count, hemoglobin (Hb), hematocrit (Hct), erythrocyte mean 
      cell volume (MCV), erythrocyte mean corpuscular hemoglobin (MCH), erythrocyte 
      mean corpuscular hemoglobin concentration (MCHC), serum ferritin, iron and total 
      iron-binding capacity (TIBC), serum erythropoietin, serum total testosterone and 
      estradiol were evaluated. Hb, Hct and red cell count rose during testosterone 
      treatment, consistently with the increase in circulating testosterone, but failed 
      to increase during estradiol treatment. A decrease in Hb, Hct and red cell count 
      was recorded in one of the two subjects during estradiol treatment, with a 
      concomitant decrease in serum testosterone. Circulating T alone is capable of and 
      sufficient to influence erythropoiesis, especially at supraphysiological dosage, 
      while circulating E(2) have not the same effect on erythropoietic parameters, 
      suggesting the hypothesis that the erythropoietic changes induced by androgens 
      are not mediated via its aromatization to estrogens.
FAU - Rochira, Vincenzo
AU  - Rochira V
AD  - Department of Medicine, Endocrinology and Metabolism, and Geriatrics, University 
      of Modena and Reggio Emilia, Argentina. vincenzo.rochira@unimore.it
FAU - Zirilli, Lucia
AU  - Zirilli L
FAU - Madeo, Bruno
AU  - Madeo B
FAU - Maffei, Laura
AU  - Maffei L
FAU - Carani, Cesare
AU  - Carani C
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081230
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 0 (Estrogens)
RN  - 0 (Hemoglobins)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Adult
MH  - Aromatase/*deficiency
MH  - Blood Chemical Analysis
MH  - Erythropoiesis/*drug effects
MH  - Estrogens/*metabolism/*pharmacology/therapeutic use
MH  - Female
MH  - Hematocrit
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Hypogonadism/drug therapy/enzymology
MH  - Male
MH  - Testosterone/*metabolism/*pharmacology/therapeutic use
EDAT- 2009/01/23 09:00
MHDA- 2009/06/02 09:00
CRDT- 2009/01/23 09:00
PHST- 2008/02/21 00:00 [received]
PHST- 2008/11/27 00:00 [revised]
PHST- 2008/12/22 00:00 [accepted]
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/06/02 09:00 [medline]
AID - S0960-0760(08)00291-4 [pii]
AID - 10.1016/j.jsbmb.2008.12.007 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):189-94. doi: 
      10.1016/j.jsbmb.2008.12.007. Epub 2008 Dec 30.