PMID- 19159824
OWN - NLM
STAT- MEDLINE
DCOM- 20091007
LR  - 20220330
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 214
IP  - 1
DP  - 2009
TI  - Aqueous extract of Rhodiola imbricata rhizome stimulates Toll-like receptor 4, 
      granzyme-B and Th1 cytokines in vitro.
PG  - 27-31
LID - 10.1016/j.imbio.2008.04.001 [doi]
AB  - Rhodiola imbricata is a medicinal plant, native to mountainous regions of Asia, 
      parts of Europe, and the Arctic. Traditionally it is recommended to help combat 
      fatigue and restore energy. It exhibits anti-stress, anti-cancer, and 
      immunostimulatory activities. However, the effect of Rhodiola on immunological 
      responses largely remains unknown. In this study, we have investigated the effect 
      of aqueous extract of R. imbricata rhizome (RAE), on Toll-like receptor-4 (TLR-4) 
      and intracellular granzyme-B expression in mouse splenocytes. Furthermore, 
      TH1/TH2 cytokine profile was analyzed in RAE-treated human peripheral blood 
      mononuclear cells (PBMCs) using multiplex flowcytomix kit. Our findings suggest 
      that RAE induces TLR-4 expression and intracellular granzyme-B in treated 
      splenocytes while RAE stimulated IL-1beta, IL-6, and TNF-alpha in human PBMCs. 
      The present study suggests that RAE stimulates the innate immune pathway and has 
      potent immunostimulatory activity, which can be used in modulating the immune 
      system of immunocompromised individuals.
FAU - Mishra, Kamla P
AU  - Mishra KP
AD  - Immunomodulation Laboratory, Defence Institute of Physiology and Allied Sciences, 
      Lucknow Road, Timarpur, Delhi 110054, India.
FAU - Ganju, Lilly
AU  - Ganju L
FAU - Chanda, Sudipta
AU  - Chanda S
FAU - Karan, Dev
AU  - Karan D
FAU - Sawhney, Ramesh C
AU  - Sawhney RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080617
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Extracts)
RN  - 0 (Toll-Like Receptor 4)
RN  - EC 3.4.21.- (Granzymes)
SB  - IM
MH  - Animals
MH  - Cell Separation
MH  - Cytokines/genetics/*metabolism
MH  - Flow Cytometry
MH  - Granzymes/genetics/immunology/*metabolism
MH  - Humans
MH  - Immunologic Factors/immunology
MH  - Inflammation Mediators/metabolism
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Plant Extracts/*pharmacology
MH  - Rhizome/immunology/metabolism
MH  - *Rhodiola
MH  - Spleen/cytology/immunology/metabolism
MH  - Th1 Cells/cytology/immunology/*metabolism
MH  - Th2 Cells/cytology/immunology/metabolism
MH  - Toll-Like Receptor 4/genetics/immunology/*metabolism
EDAT- 2009/01/23 09:00
MHDA- 2009/10/08 06:00
CRDT- 2009/01/23 09:00
PHST- 2008/01/22 00:00 [received]
PHST- 2008/04/22 00:00 [revised]
PHST- 2008/04/23 00:00 [accepted]
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/10/08 06:00 [medline]
AID - S0171-2985(08)00051-X [pii]
AID - 10.1016/j.imbio.2008.04.001 [doi]
PST - ppublish
SO  - Immunobiology. 2009;214(1):27-31. doi: 10.1016/j.imbio.2008.04.001. Epub 2008 Jun 
      17.