PMID- 19160530
OWN - NLM
STAT- MEDLINE
DCOM- 20090320
LR  - 20220330
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 40
IP  - 6
DP  - 2008
TI  - Elevated angiogenin levels in chronic heart failure.
PG  - 474-9
LID - 10.1080/07853890802001419 [doi]
AB  - BACKGROUND: Abnormal indices of angiogenesis have been reported in chronic heart 
      failure (CHF). We tested the hypothesis that circulating angiogenin (a potent 
      inducer of neovascularization in vivo) is higher in CHF patients compared with 
      controls and associated with indices of CHF severity: brain natriuretic peptide 
      (BNP), Simpson's left ventricular ejection fraction (EF), and New York Heart 
      Association (NYHA) class. METHODS: Using a cross-sectional approach, we measured 
      serum angiogenin and BNP levels in 109 consecutive patients with CHF (85 males; 
      mean age 60 (standard deviation (SD) 10 yrs) and 112 asymptomatic controls with 
      normal cardiac function and related levels to echocardiographic parameters. 
      RESULTS: Angiogenin was significantly higher in CHF patients compared to controls 
      (P < 0.001). On univariate analysis, angiogenin was positively associated with 
      age, plasma glucose, insulin, and BNP (all P < 0.001); and negatively correlated 
      with diastolic blood pressure (P = 0.04) and EF (P = 0.002). Angiogenin levels 
      increased in an ordinal fashion with NYHA class, exaggerated by the presence of 
      diabetes mellitus (pseudo R2 = 0.15, P < 0.001). In multivariate analysis, 
      angiogenin levels were only associated with deteriorating NYHA classification 
      (beta = 0.14 (95% confidence interval (CI) 0.09-0.19), P < 0.001). Angiogenin was 
      also a modest discriminator for the presence of CHF (area under the curve 0.72; 
      95% CI 0.62-0.82), P < 0.001). CONCLUSION: Angiogenin is related to worsening 
      heart failure severity (NYHA classification), with the highest levels in NYHA 
      class III. Further research is warranted to determine the validity of angiogenin 
      in a diagnostic and prognostic capacity in CHF.
FAU - Patel, Jeetesh V
AU  - Patel JV
AD  - Haemostasis Thrombosis and Vascular Biology Unit, University Department of 
      Medicine, City Hospital, Birmingham, UK.
FAU - Sosin, Michael
AU  - Sosin M
FAU - Gunarathne, Ashan
AU  - Gunarathne A
FAU - Hussain, Imran
AU  - Hussain I
FAU - Davis, Russell C
AU  - Davis RC
FAU - Hughes, Elizabeth A
AU  - Hughes EA
FAU - Lip, Gregory Y H
AU  - Lip GY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - EC 3.1.27.- (angiogenin)
RN  - EC 3.1.27.5 (Ribonuclease, Pancreatic)
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Ribonuclease, Pancreatic/*blood
MH  - Severity of Illness Index
EDAT- 2009/01/23 09:00
MHDA- 2009/03/21 09:00
CRDT- 2009/01/23 09:00
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/03/21 09:00 [medline]
AID - 792010368 [pii]
AID - 10.1080/07853890802001419 [doi]
PST - ppublish
SO  - Ann Med. 2008;40(6):474-9. doi: 10.1080/07853890802001419.