PMID- 19160537
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20090122
IS  - 0954-6634 (Print)
IS  - 0954-6634 (Linking)
VI  - 19
IP  - 5
DP  - 2008
TI  - Histologic evidence of new collagen formation using a Q-switched Nd:YAG laser in 
      periorbital rhytids.
PG  - 300-4
LID - 10.1080/09546630801961075 [doi]
AB  - OBJECTIVES: Non-ablative laser treatment has been used for improving dermal 
      toning. Laser application to dermis causes new collagen formation in terms of 
      wound healing. We aimed to study mainly histological changes in skin after the 
      use of a Q-switched Nd:YAG laser in non-ablative treatment of wrinkles. METHODS: 
      The laser was adjusted to a fluency of 7 J/cm2 with a spot size of 3 mm and a 
      pulse rate of 10 Hz to treat periorbital wrinkled areas. None of the patients had 
      received filling materials, botulinum toxin injections or any dermabrasion 
      procedures. All laser sessions were held every 15 days for a total of six 
      sessions and all patients were photographed before treatment and then 2 months 
      after the last treatment. Histological examinations were performed before laser 
      treatment and 1 month after the final treatment. RESULTS: Four of eight 
      individuals showed clinical improvement. The histological proportion of collagen 
      fibers was measured by using the Samba method. An increase in the mean optical 
      densities (MOD) of collagen fibers compared with baselines was statistically 
      significant in all patients (p<0.05). CONCLUSION: The 1064-nm Q-switched Nd:YAG 
      lasers appear to be safe and efficient for non-ablative remodeling of periorbital 
      wrinkles.
FAU - Karabudak, Ozlem
AU  - Karabudak O
AD  - Department of Dermatology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. 
      okarabudak@yahoo.com
FAU - Dogan, Bilal
AU  - Dogan B
FAU - Baloglu, Huseyin
AU  - Baloglu H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Collagen Type III)
SB  - IM
MH  - Adult
MH  - Collagen Type III/metabolism
MH  - Dermabrasion/*methods
MH  - Face
MH  - Female
MH  - Humans
MH  - *Laser Therapy
MH  - *Lasers, Solid-State
MH  - Middle Aged
MH  - *Skin Aging
EDAT- 2009/01/23 09:00
MHDA- 2009/03/04 09:00
CRDT- 2009/01/23 09:00
PHST- 2009/01/23 09:00 [entrez]
PHST- 2009/01/23 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
AID - 792239679 [pii]
AID - 10.1080/09546630801961075 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2008;19(5):300-4. doi: 10.1080/09546630801961075.