PMID- 19161456
OWN - NLM
STAT- MEDLINE
DCOM- 20090601
LR  - 20131121
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 32
IP  - 1
DP  - 2009 Feb
TI  - Tissue residue depletion of oxytetracycline after repeated intramuscular 
      administration of Oxysentin 100 in sheep.
PG  - 56-61
LID - 10.1111/j.1365-2885.2008.01003.x [doi]
AB  - The depletion profile of oxytetracycline was studied in healthy sheep after 
      intramuscular administration of Oxysentin 100, given at a dose of 10 mg 
      oxytetracycline per kg body weight once daily for 5 consecutive days. Five 
      medicated sheep were slaughtered at 0, 2, 4, 6, 9 and 12 days postmedication, and 
      injection site, muscle, fat, liver and kidney tissues were sampled and analysed 
      using a liquid chromatographic method, which was fully validated for 
      oxytetracycline and 4-epi-oxytetracycline. At day 0 postmedication, the 
      concentrations of oxytetracycline marker residue (sum of oxytetracycline and 
      4-epi-oxytetracycline) in all tissues examined were at the mg/kg level. At day 2 
      postmedication, the concentrations of oxytetracycline marker residue in all 
      injection site and kidney samples examined were higher than the corresponding 
      maximum residue limits (MRLs) established by the European Union, while the 
      concentrations in muscle and liver tissues of two and three out of five animals 
      examined, respectively, were below the corresponding MRLs. At days 4 and 6 
      postmedication, concentrations of oxytetracycline marker residue above the MRLs 
      were found only in the injection site, whereas at day 9 postmedication, all 
      observations were below the corresponding MRLs.
FAU - Fletouris, D J
AU  - Fletouris DJ
AD  - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, 
      Aristotle University, Thessaloniki, Greece. djflet@vet.auth.gr
FAU - Papapanagiotou, E P
AU  - Papapanagiotou EP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anti-Bacterial Agents)
RN  - X20I9EN955 (Oxytetracycline)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*analysis/metabolism/pharmacokinetics
MH  - Area Under Curve
MH  - Chromatography, Liquid/methods/standards/veterinary
MH  - Drug Residues/*analysis/metabolism/pharmacokinetics
MH  - Female
MH  - Injections, Intramuscular/veterinary
MH  - Kidney/chemistry
MH  - Kinetics
MH  - Liver/chemistry
MH  - Male
MH  - Muscle, Skeletal/chemistry
MH  - Organ Specificity
MH  - Oxytetracycline/*analysis/metabolism/pharmacokinetics
MH  - Sheep/*metabolism
EDAT- 2009/01/24 09:00
MHDA- 2009/06/02 09:00
CRDT- 2009/01/24 09:00
PHST- 2009/01/24 09:00 [entrez]
PHST- 2009/01/24 09:00 [pubmed]
PHST- 2009/06/02 09:00 [medline]
AID - JVP1003 [pii]
AID - 10.1111/j.1365-2885.2008.01003.x [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2009 Feb;32(1):56-61. doi: 
      10.1111/j.1365-2885.2008.01003.x.