PMID- 19162054
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20211020
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 96
IP  - 4-5
DP  - 2009 Mar 23
TI  - Long-term behavioral consequences of prenatal MDMA exposure.
PG  - 593-601
LID - 10.1016/j.physbeh.2008.12.013 [doi]
AB  - The current study sought to determine whether prenatal 
      3,4-methylenedioxy-N-methamphetamine (MDMA) exposure from E14-20 in the rat 
      resulted in behavioral sequelae in adult offspring. Prenatal MDMA exposure 
      results in increased dopaminergic fiber density in the prefrontal cortex, 
      striatum and nucleus accumbens of young rats. Since these areas are critical in 
      response to novelty, reward, attention and locomotor activity, we hypothesized 
      that prenatal MDMA exposure would produce significant changes in the performance 
      of tasks that examine such behaviors in adult rats. Adult rats prenatally exposed 
      to MDMA exhibited greater activity and spent more time in the center during a 
      novel open field test as compared to controls. This increased activity was not 
      reflected in normal home cage activity. Prenatal exposure to MDMA did not affect 
      feeding or food reward. It did not alter cocaine self-administration behaviors, 
      nor did it have an effect on the locomotor response to amphetamine challenge. 
      Finally, while prenatal MDMA did not affect performance in the radial arm maze or 
      the Morris water maze (MWM), these animals demonstrated altered performance in a 
      cued MWM paradigm. Prenatal MDMA exposure resulted in perseverative attendance to 
      a hanging cue when the platform in the MWM was removed as compared to controls. 
      Together, these data demonstrate that prenatal exposure to MDMA results in a 
      behavioral phenotype in adult rats characterized by reduced anxiety, a heightened 
      response to novelty, and "hyperattentiveness" to environmental cues during 
      spatial learning.
FAU - Thompson, Valerie B
AU  - Thompson VB
AD  - Neuroscience Graduate Program, University of Cincinnati, 231 Albert Sabin Way, 
      CVC Room 5940, ML-0537, Cincinnati, OH 45267, USA. v-thompson@hotmail.com
FAU - Heiman, Justin
AU  - Heiman J
FAU - Chambers, James B
AU  - Chambers JB
FAU - Benoit, Stephen C
AU  - Benoit SC
FAU - Buesing, William R
AU  - Buesing WR
FAU - Norman, Mantana K
AU  - Norman MK
FAU - Norman, Andrew B
AU  - Norman AB
FAU - Lipton, Jack W
AU  - Lipton JW
LA  - eng
GR  - R44 DA018538/DA/NIDA NIH HHS/United States
GR  - DA-017399/DA/NIDA NIH HHS/United States
GR  - R01 DA017399-04/DA/NIDA NIH HHS/United States
GR  - DA-019261/DA/NIDA NIH HHS/United States
GR  - R01 DA017399/DA/NIDA NIH HHS/United States
GR  - R44 DA018538-05/DA/NIDA NIH HHS/United States
GR  - DA-018538/DA/NIDA NIH HHS/United States
GR  - R21 DA019261/DA/NIDA NIH HHS/United States
GR  - R21 DA019261-02/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20081231
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Serotonin Agents)
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Association Learning/drug effects
MH  - Attention/drug effects
MH  - Behavior, Animal/*drug effects
MH  - Cocaine/pharmacology
MH  - Critical Period, Psychological
MH  - Dopamine Uptake Inhibitors/pharmacology
MH  - Exploratory Behavior/*drug effects
MH  - Female
MH  - Gestational Age
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory, Short-Term
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats
MH  - Self Administration
MH  - Serotonin Agents/*toxicity
MH  - Spatial Behavior/*drug effects
MH  - Statistics, Nonparametric
PMC - PMC2649789
MID - NIHMS85571
EDAT- 2009/01/24 09:00
MHDA- 2009/05/27 09:00
PMCR- 2010/03/23
CRDT- 2009/01/24 09:00
PHST- 2008/05/27 00:00 [received]
PHST- 2008/12/15 00:00 [revised]
PHST- 2008/12/17 00:00 [accepted]
PHST- 2009/01/24 09:00 [entrez]
PHST- 2009/01/24 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
PHST- 2010/03/23 00:00 [pmc-release]
AID - S0031-9384(08)00397-1 [pii]
AID - 10.1016/j.physbeh.2008.12.013 [doi]
PST - ppublish
SO  - Physiol Behav. 2009 Mar 23;96(4-5):593-601. doi: 10.1016/j.physbeh.2008.12.013. 
      Epub 2008 Dec 31.